Gold Mark S, Badgaiyan Rajendra D, Blum Kenneth
Departments of Psychiatry & Behavioral Sciences, Keck School of Medicine, University of Southern California, 1975 Zonal Avenue, Los Angeles, CA 90033, USA; Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA; Rivermend Health Scientific Advisory Board, 2300 Windy Ridge Parkway South East, Suite 210S, Atlanta, GA 30339, USA; Drug Enforcement Administration (DEA) Educational Foundation, Washington, DC, USA.
Laboratory of Advanced Radiochemistry and Molecular and Functioning Imaging, Department of Psychiatry, College of Medicine, University of Minnesota, Minneapolis, MN, USA.
Psychiatr Clin North Am. 2015 Sep;38(3):419-62. doi: 10.1016/j.psc.2015.05.011.
This article focuses on the shared molecular and neurogenetics of food and drug addiction tied to the understanding of reward deficiency syndrome. Reward deficiency syndrome describes a hypodopaminergic trait/state that provides a rationale for commonality in approaches for treating long-term reduced dopamine function across the reward brain regions. The identification of the role of DNA polymorphic associations with reward circuitry has resulted in new understanding of all addictive behaviors.
本文聚焦于食物成瘾和药物成瘾的共同分子及神经遗传学，这与对奖赏缺乏综合征的理解相关。奖赏缺乏综合征描述了一种多巴胺能减退的特质/状态，这为治疗奖赏脑区多巴胺功能长期减退的通用方法提供了理论依据。DNA多态性与奖赏回路关联作用的确定，带来了对所有成瘾行为的新认识。
