孕期75克口服葡萄糖耐量试验（OGTT）与50克OGTT的比较评估。

A comparative evaluation of the 75 G OGTT and the 50 G OGTT during pregnancy.

作者信息

Hanson U, Kallner A, Bergström M, Persson B, Wager J

机构信息

Department of Obstetrics and Gynecology, Karolinska Hospital, Stockholm, Sweden.

出版信息

Diabetes Res. 1989 Sep;12(1):47-9.

PMID:2630152

Abstract

The aim of the present study was to establish reference values for the diagnosis gestational diabetes (GD) by the 75 g OGTT using the 3 hr 50 g OGTT as a reference. Women with an area of greater than or equal to 42 AU in the 50 g OGTT were regarded as gestational diabetics. Sixty-one women with a 3 hr area of greater than or equal to 39 AU in the 50 g OGTT were subject also to a 3 hr 75 g OGTT within one week. 25/61 had GD according to the result of the 50 g OGTT. The 2 hr concentration in the 75 g OGTT had the highest correlation (r = 0.62, p less than 0.001) to the 3 hr-area in the 50 g OGTT. A 2 hr B-glucose concentration of greater than or equal to 8.0 mmol/l in the 75 g OGTT will give about the same number of GD patients (25/61) as a 3 hr-area of greater than or equal to 42 in the 50 g OGTT and have an acceptable sensitivity without too low specificity.

摘要

本研究的目的是以3小时50克口服葡萄糖耐量试验（OGTT）为参照，通过75克OGTT来确定诊断妊娠期糖尿病（GD）的参考值。50克OGTT中面积大于或等于42任意单位（AU）的女性被视为妊娠期糖尿病患者。61名50克OGTT中3小时面积大于或等于39 AU的女性在一周内也接受了3小时75克OGTT检查。根据50克OGTT的结果，61人中有25人患有GD。75克OGTT中2小时血糖浓度与50克OGTT中3小时面积的相关性最高（r = 0.62，p < 0.001）。75克OGTT中2小时血糖浓度大于或等于8.0 mmol/l时，诊断出的GD患者数量（25/61）与50克OGTT中3小时面积大于或等于42时大致相同，且具有可接受的敏感性，特异性不会过低。