De Carolis M P, Muzii U, Romagnoli C, Zuppa A A, Zecca E, Tortorolo G
Department of Pediatrics, Catholic University of the Sacred Heart, Rome, Italy.
Dev Pharmacol Ther. 1989;14(2):84-9.
The serum concentration of phenobarbital used as an anticonvulsant was monitored in 30 preterm babies. The therapeutic serum concentration was achieved with a loading dose of 20 mg/kg i.v., 10 min after administration. Thirty-six hours after loading, it was possible to maintain therapeutic serum levels with a daily intramuscular dose of 5 mg/kg, avoiding toxicity. A comparison of CSF and serum concentrations indicated that the drug passage to CSF is rapid and depends on a brain lesion. Serum monitoring of phenobarbital is important in preterm neonates under 30 weeks gestation and/or with severe pathological complications.
对30名早产婴儿使用苯巴比妥作为抗惊厥药时的血清浓度进行了监测。静脉注射20mg/kg的负荷剂量后10分钟，达到了治疗性血清浓度。负荷剂量36小时后，每日肌内注射5mg/kg能够维持治疗性血清水平，且未出现毒性反应。脑脊液和血清浓度的比较表明，药物进入脑脊液的速度很快，且取决于脑部病变。对于孕周小于30周和/或有严重病理并发症的早产新生儿，监测苯巴比妥的血清浓度很重要。
