Yu Kunru, Liu Xiaohua, Lin Xiaobin, Lin Lili, Feng Xiaoming
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China.
Chem Commun (Camb). 2015 Oct 14;51(80):14897-900. doi: 10.1039/c5cc05534b.
A direct strategy to obtain N-acyl amino acid oxime esters has been developed through the dynamic kinetic resolution of azlactones with oximes. In the presence of a chiral bisguanidinium salt catalyst, a variety of chiral N-acyl amino acid oxime esters were generated in excellent enantiomeric excesses (up to 97%) and high yields (up to 99%). The active oxime esters could be used in dipeptide synthesis.
通过吖内酯与肟的动态动力学拆分，已开发出一种获得N-酰基氨基酸肟酯的直接策略。在手性双胍盐催化剂的存在下，可生成多种对映体过量率极高（高达97%）且产率高（高达99%）的手性N-酰基氨基酸肟酯。活性肟酯可用于二肽合成。
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