Hafez Mohamed T, Refky Basel, Elwahab Khaled Abd, Arafa Mohammad, Abdou Islam, Elnahas Waleed
Surgical Oncology Unit, Oncology Center - Mansoura University, Mansoura, Egypt.
Pathology Department, Mansoura Faculty of Medicine, Mansoura, Egypt.
J Med Case Rep. 2015 Aug 26;9:181. doi: 10.1186/s13256-015-0668-7.
Thyroid cancer is the most common endocrine malignancy; the most common type of thyroid cancer is papillary thyroid cancer which accounts for approximately 90% of all thyroid cancers. Previously defined prognostic factors of papillary thyroid cancer include age, gender, tumor size, extrathyroidal extension, and distant metastasis. Cervical lymph node metastases are very common in patients with papillary thyroid cancer. Although papillary thyroid cancer has an excellent prognosis, lymphatic spread is associated with an increased risk of locoregional recurrence. Axillary metastasis is not a common finding in the classic type of papillary carcinoma; hence, a limited number of case reports have described the exceptional and rare metastatic spread of papillary thyroid carcinomas to the axilla.
We report a case of metastatic axillary lymphadenopathy in a 61-year-old Egyptian man with a recurrent papillary thyroid cancer. He had a history of total thyroidectomy with right radical neck dissection 18 months ago. He presented to our cancer clinic at the Oncology Centre -Mansoura University with recurrent mass at the right lower parotid region, left cervical lymphadenopathy and left axillary lymphadenopathy. Removal of the recurrent right intraparotid mass, left comprehensive neck dissection and left axillary dissection were performed and the postoperative pathology report showed infiltration of the cervical and axillary lymph nodes by metastatic papillary thyroid cancer.
Axillary lymph node enlargement in a patient with papillary thyroid cancer should be considered metastatic from thyroid until proved otherwise. Careful thorough examination of patients with recurrent thyroid cancer is essential to address any unusual metastasis.
甲状腺癌是最常见的内分泌恶性肿瘤;最常见的甲状腺癌类型是乳头状甲状腺癌,约占所有甲状腺癌的90%。先前确定的乳头状甲状腺癌预后因素包括年龄、性别、肿瘤大小、甲状腺外侵犯和远处转移。颈部淋巴结转移在乳头状甲状腺癌患者中非常常见。尽管乳头状甲状腺癌预后良好,但淋巴转移与局部区域复发风险增加相关。腋窝转移在经典型乳头状癌中并不常见;因此,仅有少数病例报告描述了乳头状甲状腺癌罕见的腋窝转移情况。
我们报告一例61岁埃及男性复发性乳头状甲状腺癌伴腋窝转移性淋巴结病的病例。他18个月前接受了全甲状腺切除术及右侧根治性颈清扫术。他因右腮腺下区复发性肿块、左侧颈部淋巴结病和左侧腋窝淋巴结病就诊于曼苏拉大学肿瘤中心的癌症诊所。进行了复发性右腮腺内肿块切除术、左侧根治性颈清扫术和左侧腋窝清扫术,术后病理报告显示颈部和腋窝淋巴结有转移性乳头状甲状腺癌浸润。
乳头状甲状腺癌患者出现腋窝淋巴结肿大,在未证实其他病因之前应考虑为甲状腺转移。对复发性甲状腺癌患者进行仔细全面的检查对于发现任何不寻常的转移至关重要。