Antoniou Asterios, Tatsis Dimitris, Papadopoulou Stavroula, Pazaitou-Panayiotou Kalliopi, Vahtsevanos Konstantinos
Oral and Maxillofacial Surgery Department, Aristotle University of Thessaloniki, General Hospital G. Papanikolaou, Papanikolaou Avenue, Thessaloniki, 57010, Greece.
Pathology Department, General Hospital G. Papanikolaou, Thessaloniki, Greece.
Hormones (Athens). 2024 Dec 9. doi: 10.1007/s42000-024-00619-x.
We present a case of metachronous metastasis of papillary thyroid carcinoma to the parotid gland, this being an extremely rare metastasis, and a literature review.
A 56-year-old female patient presented with a history of a slowly growing mass on the left side of the neck. The patient reported a medical history of thyroidectomy due to papillary thyroid carcinoma 23 years previously and neck dissection for lymph node metastases 10 years previously, with additional therapy using radioactive iodine in both cases. Computed tomography (CT) of the neck revealed a single nodular solid mass in the tail of the left parotid gland which showed heterogeneous intake of contrast agent. FNA biopsy of the left parotid gland revealed cells typical of papillary thyroid carcinoma with positive immunochemistry for TTF-1. Due to this new metastasis, a total parotidectomy with preservation of the facial nerve was performed and additional therapy with radioactive iodine was administered.
Despite the fact that papillary thyroid carcinoma has a low incidence of regional and distant metastases, there are a few rare cases with distant metastases reported in the literature. Thus, awareness, especially among endocrinologists, and a multidisciplinary approach are crucial to ensure early detection and efficient treatment of these rare cases, distant metastases being the main cause of mortality and of reduction of overall survival rate among these patients.
我们报告一例甲状腺乳头状癌异时性转移至腮腺的病例，这是一种极为罕见的转移情况，并进行文献综述。
一名56岁女性患者，颈部左侧有一缓慢生长肿块的病史。患者报告23年前因甲状腺乳头状癌行甲状腺切除术，10年前因淋巴结转移行颈部清扫术，两例均额外接受放射性碘治疗。颈部计算机断层扫描（CT）显示左腮腺尾部有一个单一的结节状实性肿块，造影剂摄取不均匀。左腮腺细针穿刺活检显示为甲状腺乳头状癌典型细胞，甲状腺转录因子-1（TTF-1）免疫化学染色阳性。鉴于出现新的转移灶，遂行保留面神经的全腮腺切除术，并给予放射性碘额外治疗。
尽管甲状腺乳头状癌区域和远处转移的发生率较低，但文献中仍有少数远处转移的罕见病例报道。因此，提高认识，尤其是内分泌科医生的认识，并采用多学科方法对于确保早期发现和有效治疗这些罕见病例至关重要，远处转移是这些患者死亡和总生存率降低的主要原因。
