肥胖儿童血液中的二十二碳六烯酸水平与代谢综合征：两者有关联吗？
Docosahexaenoic Acid Levels in Blood and Metabolic Syndrome in Obese Children: Is There a Link?
作者信息
Lassandro Carlotta, Banderali Giuseppe, Radaelli Giovanni, Borghi Elisa, Moretti Francesca, Verduci Elvira
机构信息
Department of Pediatrics, San Paolo Hospital, Department of Health Science, University of Milan, I-20142 Milan, Italy.
Microbiology Unit, Department of Health Sciences, University of Milan, I-20142 Milan, Italy.
出版信息
Int J Mol Sci. 2015 Aug 21;16(8):19989-20000. doi: 10.3390/ijms160819989.
Prevalence of metabolic syndrome is increasing in the pediatric population. Considering the different existing criteria to define metabolic syndrome, the use of the International Diabetes Federation (IDF) criteria has been suggested in children. Docosahexaenoic acid (DHA) has been associated with beneficial effects on health. The evidence about the relationship of DHA status in blood and components of the metabolic syndrome is unclear. This review discusses the possible association between DHA content in plasma and erythrocytes and components of the metabolic syndrome included in the IDF criteria (obesity, alteration of glucose metabolism, blood lipid profile, and blood pressure) and non-alcoholic fatty liver disease in obese children. The current evidence is inconsistent and no definitive conclusion can be drawn in the pediatric population. Well-designed longitudinal and powered trials need to clarify the possible association between blood DHA status and metabolic syndrome.
代谢综合征在儿科人群中的患病率正在上升。考虑到现有的不同代谢综合征定义标准，有人建议在儿童中使用国际糖尿病联盟（IDF）的标准。二十二碳六烯酸（DHA）已被证明对健康有益。关于血液中DHA水平与代谢综合征各组分之间关系的证据尚不清楚。本综述讨论了血浆和红细胞中DHA含量与IDF标准中代谢综合征各组分（肥胖、糖代谢改变、血脂谱和血压）以及肥胖儿童非酒精性脂肪性肝病之间可能存在的关联。目前的证据并不一致，在儿科人群中无法得出明确结论。需要精心设计的纵向和有足够样本量的试验来阐明血液中DHA水平与代谢综合征之间可能存在的关联。
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