Lin Tom K, Palermo Joseph J, Nathan Jaimie D, Tiao Gregory M, Hornung Lindsey N, Fei Lin, Abu-El-Haija Maisam
*Division of Pediatric Gastroenterology, Hepatology and Nutrition †Division of Pediatric Surgery ‡Division of Biostatistics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
J Pediatr Gastroenterol Nutr. 2016 Jan;62(1):118-21. doi: 10.1097/MPG.0000000000000956.
Biliary pancreatitis (BP) is common in adults and children. Current standard of care is to perform a cholecystectomy (CCE) to decrease the recurrence risk of pancreatitis. Controversy exists as to the timing of surgery, early versus delayed surgical intervention. Adult literature suggests a greater benefit of early CCE. Comparatively, there is limited pediatric literature as to the optimal timing of a CCE in children. We report a retrospective case series of children with BP who underwent early versus late CCE.
A retrospective chart review was performed of children with BP for a period of 45 months. Reviewed information included patient demographics, timing of CCE, and the occurrence of adverse events preceding or following surgical intervention. Early CCE was defined as surgery during the index admission; late CCE was defined as surgery during a subsequent admission.
Nineteen children and adolescents (17 girls) were identified to have had BP with a subsequent CCE. Cholecystectomy was performed early in 9 patients with no adverse events. Ten patients had delayed surgery with 4 occurrences of adverse clinical events (recurrence of pancreatitis or biliary colic abdominal pain) while awaiting their CCE.
Adverse biliary-related events occur at a higher rate in children with mild BP who undergo a delayed CCE when compared to early CCE performance. Early CCE is safe to perform in children with mild BP.
胆源性胰腺炎(BP)在成人和儿童中都很常见。目前的护理标准是进行胆囊切除术(CCE)以降低胰腺炎的复发风险。关于手术时机存在争议,即早期手术干预与延迟手术干预。成人文献表明早期CCE有更大益处。相比之下,关于儿童CCE的最佳时机的儿科文献有限。我们报告了一组接受早期与晚期CCE的BP患儿的回顾性病例系列。
对45个月期间的BP患儿进行回顾性病历审查。审查的信息包括患者人口统计学、CCE时机以及手术干预前后不良事件的发生情况。早期CCE定义为在首次住院期间进行手术;晚期CCE定义为在随后的住院期间进行手术。
确定19名儿童和青少年(17名女孩)患有BP并随后进行了CCE。9名患者早期进行了胆囊切除术,无不良事件。10名患者延迟手术,在等待CCE期间有4例发生不良临床事件(胰腺炎复发或胆绞痛腹痛)。
与早期进行CCE相比,轻度BP患儿延迟进行CCE时,不良胆源性相关事件的发生率更高。轻度BP患儿早期进行CCE是安全的。