TCF7L2基因多态性与乳腺癌易感性的关联：一项荟萃分析。
Association between TCF7L2 polymorphisms and breast cancer susceptibility: a meta-analysis.
作者信息
Wang Feng, Jiang Lixin, Li Jianlin, Yu Xiao, Li Mingchuan, Wu Guochang, Yu Zhenyu, Zhou Kai, Chu Haidi, Zhai Huiyuan
机构信息
Department of Breast Disease, The Second Hospital of Shandong University 247 Beiyuan Street, Tianqiao District, Jinan 250033, Shandong, China ; Department of Breast Disease, Beijing Tiantan Hospital, Capital Medical University Beijing 100050, China.
Department of Gastrointestinal Surgery, Yantai Yuhuangding Hospital 20 Yuhuangding East Road, Yantai 264000, Shandong, China.
出版信息
Int J Clin Exp Med. 2015 Jun 15;8(6):9355-61. eCollection 2015.
AIM
Our aim was to investigate the relationship between transcription factor 7-like 2 (TCF7L2) polymorphisms and breast cancer susceptibility.
METHODS
PubMed, Embase and CNKI databases were used to search the related studies investigating the correlation between TCF7L2 polymorphisms and breast cancer susceptibility. Pooled ORs and 95% CIs, based on five genetic models, were applied to estimate the association betweenTCF7L2 polymorphisms and breast cancer. A fixed-effect model or a random-effect model was applied according to the between-study heterogeneity.
RESULTS
We analyzed six single nucleotide polymorphisms (SNPs) in TCF7L2 gene, namely rs12255372, rs7903146, rs7900150, rs3750805, rs1225404 and rs7003146. The increased risk of breast cancer was associated with TCF7L2 polymorphisms (22 vs. 11: OR=1.16, 95% CI=1.02-1.32; 22+12 vs. 11: OR=1.06, 95% CI=1.02-1.10; 22 vs. 11+12: OR=1.15, 95% CI=1.04-1.27; 2 vs. 1: OR=1.07, 95% CI=1.02-1.13; 12 vs. 11: OR=1.05, 95% CI=1.01-1.09). Among the locus, rs7903146 polymorphism was significantly associated with the risk for breast cancer under five genetic models (TT vs. CC: OR=1.29, 95% CI=1.08-1.53; TT+CT vs. CC: OR=1.09, 95% CI=1.01-1.18; TT vs. CC+CT: OR=1.24, 95% CI=1.05-1.48; T vs. C: OR=1.11, 95% CI=1.04-1.19; CT vs. CC: OR=1.08, 95% CI=1.00-1.17). Additionally, rs7900150 also showed effects on the susceptibility of breast cancer (TT vs. AA: OR=1.22, 95% CI=1.07-1.39; TT+AT vs. AA: OR=1.06, 95% CI=1.00-1.14; TT vs. AA+AT: OR=1.21, 95% CI=1.07-1.37; T vs. A: OR=1.09, 95% CI=1.02-1.15; AT vs. AA: OR=1.04, 95% CI=1.01-1.33). Meanwhile, we found that rs3750805 polymorphism could increased the risk for breast cancer (TT+AT vs. AA: OR=1.12, 95% CI=1.01-1.24).
CONCLUSION
Our meta-analysis demonstrates that TCF7L2 polymorphisms may increase the risk for breast cancer.
目的
我们的目的是研究转录因子7样2（TCF7L2）基因多态性与乳腺癌易感性之间的关系。
方法
使用PubMed、Embase和中国知网数据库检索关于TCF7L2基因多态性与乳腺癌易感性相关性的相关研究。基于五种遗传模型的合并比值比（OR）和95%置信区间（CI）用于评估TCF7L2基因多态性与乳腺癌之间的关联。根据研究间的异质性应用固定效应模型或随机效应模型。
结果
我们分析了TCF7L2基因中的六个单核苷酸多态性（SNP），即rs12255372、rs7903146、rs7900150、rs3750805、rs1225404和rs7003146。乳腺癌风险增加与TCF7L2基因多态性相关（22 vs. 11：OR = 1.16，95%CI = 1.02 - 1.32；22 + 12 vs. 11：OR = 1.06，95%CI = 1.02 - 1.10；22 vs. 11 + 12：OR = 1.15，95%CI = 1.04 - 1.27；2 vs. 1：OR = 1.07，95%CI = 1.02 - 1.13；12 vs. 11：OR = 1.05，95%CI = 1.01 - 1.09）。在这些位点中，rs7903146基因多态性在五种遗传模型下与乳腺癌风险显著相关（TT vs. CC：OR = 1.29，95%CI = 1.08 - 1.53；TT + CT vs. CC：OR = 1.09，95%CI = 1.01 - 1.18；TT vs. CC + CT：OR = 1.24，95%CI = 1.05 - 1.48；T vs. C：OR = 1.11，95%CI = 1.04 - 1.19；CT vs. CC：OR = 1.08，95%CI = 1.00 - 1.17）。此外，rs7900150也显示出对乳腺癌易感性的影响（TT vs. AA：OR = 1.22，95%CI = 1.07 - 1.39；TT + AT vs. AA：OR = 1.06，95%CI = 1.00 - 1.14；TT vs. AA + AT：OR = 1.21，95%CI = 1.07 - 1.37；T vs. A：OR = 1.09，95%CI = 1.02 - 1.15；AT vs. AA：OR = 1.04，95%CI = 1.01 - 1.33）。同时，我们发现rs3750805基因多态性可增加乳腺癌风险（TT + AT vs. AA：OR = 1.12，95%CI = 1.01 - 1.24）。
结论
我们的荟萃分析表明，TCF7L2基因多态性可能增加乳腺癌风险。
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