CYP24A1 基因遗传多态性与癌症易感性的关系：一项包含 40640 例个体的荟萃分析
Genetic polymorphisms of CYP24A1 gene and cancer susceptibility: a meta-analysis including 40640 subjects.
机构信息
Department of Radiotherapy, Ruian People's Hospital, Ruian, 325200, Zhejiang, China.
Gannan Medical University, Ganzhou, 341000, Jiangxi, China.
出版信息
World J Surg Oncol. 2023 Sep 5;21(1):279. doi: 10.1186/s12957-023-03156-w.
BACKGROUND
Whether cytochrome P450 24A1 (CYP24A1) polymorphism is associated with cancer susceptibility, the individual study results are still controversial. Therefore, we performed a comprehensive study to identify the association of CYP24A1 polymorphisms (rs4809960, rs6068816, rs2296241, rs4809957, rs2762939) with cancer susceptibility.
METHODS
Electronic databases including Cochrane Library, PubMed, and Embase were systematically retrieved for relevant publications. Fixed or random-effect model was selected to calculate odds ratios (ORs) with their 95% confidence intervals (95%CI).
RESULTS
Eighteen published articles were identified. The results indicated that rs4809960 polymorphism was associated with a decreased cancer risk in Caucasian (TT vs. TC+CC: P=0.035; C vs. T: P=0.016) and Asian population (CC vs. TC+TT: OR P=0.044; TT vs. TC+CC: P=0.021; CC vs. TT: P=0.020; C vs. T: P=0.008) and breast cancer risk (TT vs. TC+CC: P = 0.007; TC vs. TT: P=0.004; C vs. T: P=0.033). A significant association was found between rs2296241 polymorphism and esophageal squamous cell carcinoma risk (AA vs. GG+AG: P = 0.023) and prostate cancer susceptibility (A vs. G: P=0.022). Furthermore, rs4809957 polymorphism was associated with prostate cancer susceptibility in Caucasian (GG vs. GA+AA: P=0.029; GA vs. GG: P=0.022) and breast cancer susceptibility (AA vs. GG+GA: P=0.012; AA vs. GG, P=0.010; A vs. G: P=0.024). Additionally, rs6068816 polymorphism significantly decreased the lung cancer (CC vs. CT+TT: P = 0.016; TT vs. CC: P = 0.044; CT vs. CC: P = 0.036; T vs. C: P = 0.016) and breast cancer risk (TT vs. CC+CT: P = 0.043; TT vs. CC: P = 0.039). No association was found for rs2762939 polymorphism with overall cancer risk. However, for rs2296241, rs4809957, and rs6068816 polymorphisms, there were no significant differences after the Bonferroni correction.
CONCLUSION
The meta-analysis suggested that rs4809960 was associated with cancer risk and might be a genetic marker for predicting cancer risk. More large-scale and large-sample studies are necessary to further confirm these results.
背景
细胞色素 P450 24A1（CYP24A1）多态性是否与癌症易感性相关，个别研究结果仍存在争议。因此，我们进行了一项综合研究，以确定 CYP24A1 多态性（rs4809960、rs6068816、rs2296241、rs4809957、rs2762939）与癌症易感性的关系。
方法
系统检索 Cochrane 图书馆、PubMed 和 Embase 等电子数据库，以获取相关文献。使用固定或随机效应模型计算比值比（OR）及其 95%置信区间（95%CI）。
结果
共确定了 18 篇已发表的文章。结果表明，rs4809960 多态性与高加索人群（TT 与 TC+CC：P=0.035；C 与 T：P=0.016）和亚洲人群（CC 与 TC+TT：OR P=0.044；TT 与 TC+CC：P=0.021；CC 与 TT：P=0.020；C 与 T：P=0.008）以及乳腺癌风险（TT 与 TC+CC：P=0.007；TC 与 TT：P=0.004；C 与 T：P=0.033）呈负相关。rs2296241 多态性与食管鳞状细胞癌风险（AA 与 GG+AG：P=0.023）和前列腺癌易感性（A 与 G：P=0.022）显著相关。此外，rs4809957 多态性与高加索人群的前列腺癌易感性（GG 与 GA+AA：P=0.029；GA 与 GG：P=0.022）和乳腺癌易感性（AA 与 GG+GA：P=0.012；AA 与 GG，P=0.010；A 与 G：P=0.024）相关。此外，rs6068816 多态性显著降低了肺癌（CC 与 CT+TT：P=0.016；TT 与 CC：P=0.044；CT 与 CC：P=0.036；T 与 C：P=0.016）和乳腺癌风险（TT 与 CC+CT：P=0.043；TT 与 CC：P=0.039）。rs2762939 多态性与总体癌症风险无显著相关性。然而，在经过 Bonferroni 校正后，rs2296241、rs4809957 和 rs6068816 多态性没有显著差异。
结论
荟萃分析表明，rs4809960 与癌症风险相关，可能是预测癌症风险的遗传标志物。需要进行更多大规模、大样本的研究来进一步证实这些结果。
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