Hope Katharine L, Boedeker Nancy C, Gordon Sebastian S, Walsh Timothy F
Wildlife Health Sciences, Smithsonian's National Zoological Park, Washington, District of Columbia, USA.
North Hobart Veterinary Hospital, North Hobart, Tasmania, Australia.
Comp Med. 2015 Aug;65(4):348-51.
A 20-y-old, male, ring-tailed lemur (Lemur catta) presented with a large, firm mass on the proximal caudolateral left femur. The animal displayed no clinical signs associated with the mass. Radiographs revealed a mineralized mass protruding from the femur, with an intact femoral cortex. Histopathology diagnosed osteochondroma in view of the presence of a peripheral layer of cartilage with progressive endochondral ossification and typical remodeling of bony trabeculae. The mass grew quickly after the initial biopsy, and a second surgery to debulk 95% of the tumor was performed. Histopathologic features of the larger samples were similar to those of the initial biopsies, with the cartilage layer being discontinuous and development of bone from some borders progressing directly from a periost-like layer. Nineteen months after the second surgery, the mass had regrown and extended further proximally on the femur toward the epiphysis, but the animal remained asymptomatic, and additional debulking was not attempted. This report is the first description of an osteochondroma in a prosimian and describes unique behavior of the tumor compared with osteochondromas found in humans, dogs, and cats.
一只20岁的雄性环尾狐猴（Lemur catta）左侧股骨近端后外侧出现一个大的、质地坚硬的肿块。该动物未表现出与肿块相关的临床症状。X线片显示有一个矿化肿块从股骨突出，股骨皮质完整。鉴于存在一层外周软骨，伴有进行性软骨内成骨和典型的骨小梁重塑，组织病理学诊断为骨软骨瘤。初次活检后肿块迅速生长，遂进行了第二次手术，切除了95%的肿瘤。较大样本的组织病理学特征与初次活检相似，软骨层不连续，部分边界处的骨形成直接从类似骨膜的层开始。第二次手术后19个月，肿块复发并在股骨上进一步向近端延伸至骨骺，但该动物仍无症状，未尝试再次减瘤。本报告首次描述了原猴亚目动物中的骨软骨瘤，并描述了该肿瘤与人类、犬类和猫类骨软骨瘤相比的独特行为。
