Yu Maomao, Jie Xu, Xu Lu, Chen Cong, Shen Wanli, Cao Yini, Lian Guan, Qi Rong
Peking University Institute of Cardiovascular Sciences, Peking University Health Science Center , Beijing 100191, China.
School of Pharmacy, Shihezi University , Shihezi 832000, China.
Biomacromolecules. 2015 Sep 14;16(9):2588-98. doi: 10.1021/acs.biomac.5b00979. Epub 2015 Sep 1.
Dendrimers, as a type of artificially synthesized polymers, have been increasingly attracting attention in many research fields, including the material and medical sciences, due to their unique characteristics that include their highly branched and well-defined molecular architecture, multivalency and tunable chemical compositions. These advantages make dendrimers potential carriers for the delivery of therapeutic and diagnostic agents. Herein, we review the recent advances in dendrimer research for the prevention and treatment of cardiovascular diseases, with special focus on their applications as carriers for drug and gene delivery, as contrast agents, and as potential new drugs.
树枝状大分子作为一种人工合成的聚合物，因其独特的特性，包括高度分支且结构明确的分子结构、多价性和可调节的化学成分，在包括材料科学和医学在内的许多研究领域越来越受到关注。这些优势使树枝状大分子成为治疗和诊断剂递送的潜在载体。在此，我们综述了树枝状大分子在预防和治疗心血管疾病研究方面的最新进展，特别关注其作为药物和基因递送载体、造影剂以及潜在新药的应用。
