Sharma Mayank, Sharma Rajesh, Jain Dinesh Kumar
School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore, India.
College of Pharmacy, IPS Academy, Indore, India.
Scientifica (Cairo). 2016;2016:8525679. doi: 10.1155/2016/8525679. Epub 2016 Apr 30.
Oral administration is the most convenient route among various routes of drug delivery as it offers high patient compliance. However, the poor aqueous solubility and poor enzymatic/metabolic stability of drugs are major limitations in successful oral drug delivery. There are several approaches to improve problems related to hydrophobic drugs. Among various approaches, nanotechnology based drug delivery system has potential to overcome the challenges associated with the oral route of administration. Novel drug delivery systems are available in many areas of medicine. The application of these systems in the treatment of hypertension continues to broaden. The present review focuses on various nanocarriers available in oral drug administration for improving solubility profile, dissolution, and consequently bioavailability of hydrophobic antihypertensive drugs.
口服给药是各种给药途径中最方便的途径，因为它具有很高的患者依从性。然而，药物的水溶性差以及酶促/代谢稳定性差是口服给药成功的主要限制因素。有几种方法可以改善与疏水性药物相关的问题。在各种方法中，基于纳米技术的药物递送系统有潜力克服与口服给药途径相关的挑战。新型药物递送系统在医学的许多领域都有应用。这些系统在高血压治疗中的应用不断扩大。本综述重点关注口服给药中可用的各种纳米载体，以改善疏水性抗高血压药物的溶解度、溶出度，从而提高其生物利用度。
