Rosnowska M, Langer D, Cendrowski W
Pol Tyg Lek. 1989 Jun 12;44(24):575-8.
Blood free fatty acids and their composition were investigated in 25 alcohol abusers hospitalized for detoxication. Blood samples were collected at the admission to the hospital and following detoxication therapy. Free fatty acids were assayed with Dole's technique whereas their composition with gas chromatography. Liver functioning was evaluated with the aid of the following tests: AspAT, AlAT, AP, bilirubin concentration, and thymol test. An increase in free fatty acids concentration was seen in 12 out of 25 patients prior to detoxication. Blood serum free fatty acids were within normal limits in all except one patient after detoxication. A decrease in linoleic acid levels was seen in both total fatty acids and free fatty acids before detoxication. It is more marked in total fatty acids than in free fatty acids and persists after detoxication. Linoleic acid content in free fatty acids returns to the normal values following detoxication. An increase in oleic acid level accompanying a decrease in linoleic acid concentration is probably secondary to the stimulation with hydrogen excess formed during alcohol fermentation.
对25名因解毒而住院的酗酒者的血液游离脂肪酸及其组成进行了研究。在入院时和解毒治疗后采集血样。游离脂肪酸采用多尔氏技术进行测定，而其组成则采用气相色谱法进行分析。借助以下检查评估肝功能：谷草转氨酶、谷丙转氨酶、碱性磷酸酶、胆红素浓度和麝香草酚浊度试验。25名患者中有12名在解毒前游离脂肪酸浓度升高。除一名患者外，所有患者在解毒后血清游离脂肪酸均在正常范围内。解毒前总脂肪酸和游离脂肪酸中的亚油酸水平均下降。总脂肪酸中的下降比游离脂肪酸中更明显，且在解毒后仍持续存在。解毒后游离脂肪酸中的亚油酸含量恢复到正常水平。亚油酸浓度降低伴随油酸水平升高，这可能继发于酒精发酵过程中形成的过量氢气的刺激。
