先兆子痫中的必需脂肪酸模式。

Essential fatty acid patterns in preeclampsia.

作者信息

Ogburn P L, Turner S I, Williams P P, Johnson S B, Holman R T

出版信息

Zentralbl Gynakol. 1986;108(16):983-9.

Abstract

Fatty acid patterns were determined for maternal and cord sera from normal and preeclamptic pregnancies using gas liquid chromatography. Ten normal and 11 preeclamptic maternal sera were used; 6 preeclamptic and 6 normal cord sera were measured. Fatty acid patterns were measured in the nonesterified fatty acids (NEFA), the triglycerides (TG), the cholesterol esters (CE), and the phospholipids (PL). Preeclampsia showed significant differences in the essential fatty acid patterns in the maternal and cord sera compared to normal pregnancy. Oleic acid, an early indicator of essential fatty acid deficiency, made up a significantly greater proportion of preeclamptic cord blood NEFA, TG, and PL than in normal cord blood. Abnormalities in essential fatty acid patterns may be associated with decreased prostacyclin production and dysmaturity which may be seen with preeclampsia.

摘要

采用气相色谱法测定正常妊娠和先兆子痫妊娠孕妇及脐带血清中的脂肪酸模式。使用了10份正常孕妇血清和11份先兆子痫孕妇血清；测定了6份先兆子痫脐带血清和6份正常脐带血清。对非酯化脂肪酸（NEFA）、甘油三酯（TG）、胆固醇酯（CE）和磷脂（PL）中的脂肪酸模式进行了测定。与正常妊娠相比，先兆子痫孕妇及脐带血清中的必需脂肪酸模式存在显著差异。油酸是必需脂肪酸缺乏的早期指标，与正常脐带血相比，先兆子痫脐带血NEFA、TG和PL中油酸所占比例显著更高。必需脂肪酸模式异常可能与前列环素生成减少和成熟障碍有关，这在先兆子痫中可见。