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催乳素/血管抑制素轴的原理。

Principles of the prolactin/vasoinhibin axis.

作者信息

Triebel Jakob, Bertsch Thomas, Bollheimer Cornelius, Rios-Barrera Daniel, Pearce Christy F, Hüfner Michael, Martínez de la Escalera Gonzalo, Clapp Carmen

机构信息

Institute for Clinical Chemistry, Laboratory Medicine and Transfusion Medicine, Paracelsus Medical University, Nuremberg, Germany;

Institute for Biomedicine of Aging, Friedrich-Alexander Universität Erlangen-Nürnberg, Nuremberg, Germany;

出版信息

Am J Physiol Regul Integr Comp Physiol. 2015 Nov 15;309(10):R1193-203. doi: 10.1152/ajpregu.00256.2015. Epub 2015 Aug 26.

DOI:10.1152/ajpregu.00256.2015
PMID:26310939
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4666935/
Abstract

The hormonal family of vasoinhibins, which derive from the anterior pituitary hormone prolactin, are known for their inhibiting effects on blood vessel growth, vasopermeability, and vasodilation. As pleiotropic hormones, vasoinhibins act in multiple target organs and tissues. The generation, secretion, and regulation of vasoinhibins are embedded into the organizational principle of an axis, which integrates the hypothalamus, the pituitary, and the target tissue microenvironment. This axis is designated as the prolactin/vasoinhibin axis. Disturbances of the prolactin/vasoinhibin axis are associated with the pathogenesis of retinal and cardiac diseases and with diseases occurring during pregnancy. New phylogenetical, physiological, and clinical implications are discussed.

摘要

血管抑制素激素家族源自垂体前叶激素催乳素，以其对血管生长、血管通透性和血管舒张的抑制作用而闻名。作为多效性激素，血管抑制素作用于多个靶器官和组织。血管抑制素的产生、分泌和调节融入了一个轴的组织原则，该轴整合了下丘脑、垂体和靶组织微环境。这个轴被称为催乳素/血管抑制素轴。催乳素/血管抑制素轴的紊乱与视网膜和心脏疾病的发病机制以及孕期发生的疾病有关。文中讨论了新的系统发育、生理和临床意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7931/4666935/280568809a47/zh60191588390004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7931/4666935/980d2fd95cb6/zh60191588390001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7931/4666935/784566d8522b/zh60191588390002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7931/4666935/099fe6319a5f/zh60191588390003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7931/4666935/280568809a47/zh60191588390004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7931/4666935/980d2fd95cb6/zh60191588390001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7931/4666935/784566d8522b/zh60191588390002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7931/4666935/099fe6319a5f/zh60191588390003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7931/4666935/280568809a47/zh60191588390004.jpg

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Rationale and design of a randomized, controlled multicentre clinical trial to evaluate the effect of bromocriptine on left ventricular function in women with peripartum cardiomyopathy.一项评估溴隐亭对围产期心肌病女性左心室功能影响的随机对照多中心临床试验的原理与设计。
Clin Res Cardiol. 2015 Nov;104(11):911-7. doi: 10.1007/s00392-015-0869-5. Epub 2015 May 31.
2
New insights in prolactin: pathological implications.催乳素的新认识：病理意义。
Nat Rev Endocrinol. 2015 May;11(5):265-75. doi: 10.1038/nrendo.2015.36. Epub 2015 Mar 17.
3
On the Path toward Classifying Hormones of the Vasoinhibin-Family.
轻度升高的血清催乳素水平可能是2型糖尿病患者预防颈动脉内膜中层增厚的一个保护因素。
Endocr Connect. 2024 Dec 19;14(1). doi: 10.1530/EC-24-0285. Print 2025 Jan 1.
4
Retinal prolactin isoform PRLΔE1 sustains rod disease in inherited retinal degenerations.视网膜催乳素同工型 PRLΔE1 维持遗传性视网膜变性中的 rod 疾病。
Cell Death Dis. 2024 Sep 18;15(9):682. doi: 10.1038/s41419-024-07070-1.
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Immunometric and functional measurement of endogenous vasoinhibin in human sera.免疫计量法和功能性检测人血清中的内源性血管抑制素。
Front Endocrinol (Lausanne). 2024 Apr 29;15:1345996. doi: 10.3389/fendo.2024.1345996. eCollection 2024.
6
Vasoinhibin's Apoptotic, Inflammatory, and Fibrinolytic Actions Are in a Motif Different From Its Antiangiogenic HGR Motif.血管抑素的促凋亡、促炎和纤溶作用与其抗血管生成 HGR 基序不同。
Endocrinology. 2023 Dec 23;165(2). doi: 10.1210/endocr/bqad185.
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