Hauge Christian Riise, Rasmussen Alice, Piet Jacob, Bonde Jens Peter, Jensen Claus, Sumbundu Antonia, Skovbjerg Sine
The Danish Research Centre for Chemical Sensitivities, Department of Dermato-Allergology, Copenhagen University Hospital Gentofte, Ledreborg Alle 40, 2.th, Gentofte, 2820, Copenhagen, Denmark.
Psychiatric Centre, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark.
J Psychosom Res. 2015 Dec;79(6):628-34. doi: 10.1016/j.jpsychores.2015.06.010. Epub 2015 Jul 16.
Multiple chemical sensitivity (MCS) is a medically unexplained condition characterized by symptoms from multiple organ systems following the perception of common odorants. The condition can cause severe functional impairment for afflicted individuals. The aim of this study was to assess the effects of mindfulness-based cognitive therapy (MBCT) for individuals with MCS.
The intention-to-treat sample (ITT) included 69 individuals who had been randomized to either MBCT or treatment as usual (TAU). The primary outcome measure was the Quick Environmental Exposure and Sensitivity Inventory (QEESI), which measures the following aspects of
impact of MCS on daily life, symptoms, and reactions following chemical exposures. Secondary outcome measures included the Brief Illness Perception Questionnaire (BIPQ) and the anxiety and depression subscales of the symptom checklist 92 (SCL-92). Participants were assessed at baseline and post treatment, and at follow-up periods of 6- and 12-months.
We found no effect of MBCT on the primary outcome, nor did we find an effect on levels of depression or anxiety. We did, however, find positive changes in illness perceptions, which were sustained at 12-month follow-up. Dropout rates were low, suggesting MBCT was well received and regarded as an acceptable intervention by individuals with MCS.
Overall, these results suggest that MBCT does not change overall illness status in individuals with MCS, but that MBCT positively changes emotional and cognitive representations. Possible explanations for these results are discussed.
多重化学物质敏感症（MCS）是一种医学上无法解释的病症，其特征是在接触常见气味剂后多个器官系统出现症状。这种病症会给患者造成严重的功能障碍。本研究的目的是评估基于正念的认知疗法（MBCT）对MCS患者的影响。
意向性治疗样本（ITT）包括69名被随机分配到MBCT组或常规治疗（TAU）组的个体。主要结局指标是快速环境暴露与敏感性量表（QEESI），该量表测量MCS的以下几个方面：MCS对日常生活的影响、症状以及接触化学物质后的反应。次要结局指标包括简易疾病认知问卷（BIPQ）以及症状自评量表92（SCL-92）中的焦虑和抑郁分量表。在基线、治疗后以及6个月和12个月的随访期对参与者进行评估。
我们发现MBCT对主要结局没有影响，对抑郁或焦虑水平也没有影响。然而，我们确实发现疾病认知有积极变化，这种变化在12个月的随访中持续存在。脱落率较低，这表明MBCT很受欢迎，被MCS患者视为可接受的干预措施。
总体而言，这些结果表明MBCT不会改变MCS患者的整体疾病状态，但会积极改变其情绪和认知表征。对这些结果的可能解释进行了讨论。
