长期苯妥英治疗所致血清IgA缺乏症。
Serum IgA deficiency induced by prolonged phenytoin treatment.
作者信息
Talesnik E, Rivero S J, González B
出版信息
Rev Invest Clin. 1989 Oct-Dec;41(4):331-5.
In a longitudinal study we have evaluated several immunological parameters in thirty three epileptic children and adolescents 4 to 14 years old treated with phenytoin, and matched normal controls. The patients had significantly lower levels than normal controls of IgA (153 +/- 89 vs 236 +/- 128 mg/dL p less than 0.001) and IgM (155 +/- 58 vs 217 +/- 105 mg/dL p less than 0.01). The decrease in serum IgA levels correlated with the length of treatment (r = 0.44, p less than 0.03). Eight of the patients had IgA deficiency. In 7 of these children, T lymphocytes subpopulations were determined. The results did not differ significantly from the matched controls.
在一项纵向研究中，我们评估了33名4至14岁接受苯妥英治疗的癫痫儿童和青少年以及相匹配的正常对照者的多项免疫参数。患者的IgA（153±89 vs 236±128 mg/dL，p<0.001）和IgM（155±58 vs 217±105 mg/dL，p<0.01）水平显著低于正常对照者。血清IgA水平的降低与治疗时长相关（r = 0.44，p<0.03）。8名患者存在IgA缺乏。在其中7名儿童中，测定了T淋巴细胞亚群。结果与相匹配的对照者无显著差异。
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