Matsuoka H, Okada J, Takahashi T, Matsuoka M, Sato C, Torii S
Clin Exp Immunol. 1983 Aug;53(2):423-8.
Of 10 epileptic children with IgA deficiency, one showed normal IgA synthesis and secretion on in vitro pokeweed mitogen (PWM) stimulated lymphocyte culture in contrast to IgA deficiency in vivo, two showed IgA synthesis in cytoplasm without any release of IgA into the supernatant and seven failed to synthesize IgA. Co-cultures with allogeneic T or B cells in various combinations with PWM showed intrinsic IgA-B cell defect without T cell defect in two of the second group affected at IgA secretion and in five of the third group, and intrinsic IgA-B defect with dysfunction of T cells in two of the third group. Thus, the IgA deficiency in these epileptic patients was demonstrated to be heterogenous.
在10名患有IgA缺乏症的癫痫儿童中，1名在体外商陆有丝分裂原（PWM）刺激的淋巴细胞培养中显示出正常的IgA合成和分泌，与体内IgA缺乏形成对比；2名在细胞质中显示出IgA合成，但没有任何IgA释放到上清液中；7名未能合成IgA。在第二组中，有2名IgA分泌受影响的患者以及第三组中的5名患者，与PWM以各种组合与同种异体T细胞或B细胞共培养，显示出内在的IgA-B细胞缺陷，而无T细胞缺陷；第三组中的2名患者显示出内在的IgA-B缺陷以及T细胞功能障碍。因此，这些癫痫患者的IgA缺乏被证明是异质性的。
