Berenstein Alejandro
J Neurointerv Surg. 2016 Sep;8(9):934-9. doi: 10.1136/neurintsurg-2015-011930. Epub 2015 Aug 26.
Occlusion of canine bifurcation and sidewall aneurysms was undertaken with a new liquid embolic agent (PHIL 35) assisted by a high-density partially retrievable stent (FRED) with preservation of the carotid artery.
Three dogs were used as acute preparations for development of the technique and two were used for chronic studies lasting 90 days. In one animal we intentionally did not completely fill the aneurysm to determine the long-term results of incomplete treatment. The degree of occlusion, carotid artery compromise, and dislodgement and/or migration of embolic material in treated aneurysms were assessed.
All aneurysms planned for complete obliteration were totally occluded successfully. By design, we partially occluded one aneurysm. In this aneurysm, angiography performed at 30 days revealed less filling, but at 90 days it had persistent small residual filling. We did not detect any distal embolization during the injection and no angiographic occlusions, change in configuration, or delayed migration of the embolic material were found. In the inspected stent, no foreign material was noted. In four animals we successfully removed the stent with preservation of the integrity of the carotid artery. In the fifth we intentionally left both stents deployed.
We have developed a new treatment for cerebral aneurysms using a combination of a retrievable stent and a new liquid embolic agent.
使用一种新型液体栓塞剂（PHIL 35）并辅以高密度部分可回收支架（FRED），在保留颈动脉的情况下对犬类分叉部和侧壁动脉瘤进行栓塞。
三只犬用作该技术开发的急性实验对象，两只犬用于为期90天的慢性研究。在一只动物中，我们故意未完全填充动脉瘤以确定不完全治疗的长期结果。评估了治疗后动脉瘤的闭塞程度、颈动脉受累情况以及栓塞材料的移位和/或迁移情况。
所有计划完全闭塞的动脉瘤均成功完全闭塞。按照设计，我们部分闭塞了一个动脉瘤。在这个动脉瘤中，30天时进行的血管造影显示充盈减少，但90天时仍有持续的小残留充盈。注射过程中未检测到任何远端栓塞，也未发现栓塞材料的血管造影闭塞、形态改变或延迟迁移。在检查的支架中，未发现异物。在四只动物中，我们成功取出了支架，同时保留了颈动脉的完整性。在第五只动物中，我们故意保留了两个支架。
我们开发了一种使用可回收支架和新型液体栓塞剂联合治疗脑动脉瘤的新方法。
