Garcez Michelle L, Falchetti Ana Carolina B, Mina Francielle, Budni Josiane
Programa de Pós-Graduação em Ciências da Saúde, Laboratório de Neurociências, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, BR.
An Acad Bras Cienc. 2015 Aug;87(2 Suppl):1461-73. doi: 10.1590/0001-3765201520140716. Epub 2015 Aug 25.
Alzheimer's disease (AD) is the most common cause of dementia and has become a severe public health issue. It is estimated that globally, 35.6% of people have some form of dementia. This number is expected to double by 2030, and possibly even triple by 2050. The disease is associated with deficits in cognition/memory and a reduced ability in coping with everyday life. Moreover, patients can experience behavioral alterations such as mood swings, depression and hallucinations. Therefore, it is common to find the presence of neuropsychiatric comorbidities such as depression, schizophrenia and bipolar disorder during the course or development of AD. These disorders can become severe enough to interfere with the patients daily functioning, and can worsen the course of the disease. However, little is known about the causal relationship between psychiatric comorbidities and AD, or the reasons for the predisposition of some individuals to such disorders. Therefore, the purpose of this review is to clarify the causal relationship between depression, schizophrenia and bipolar disorder with AD.
阿尔茨海默病（AD）是痴呆最常见的病因，已成为一个严重的公共卫生问题。据估计，全球有35.6%的人患有某种形式的痴呆症。预计到2030年，这一数字将翻倍，到2050年甚至可能增至三倍。该疾病与认知/记忆缺陷以及应对日常生活能力下降有关。此外，患者可能会出现行为改变，如情绪波动、抑郁和幻觉。因此，在AD病程或发展过程中，常发现存在神经精神共病，如抑郁症、精神分裂症和双相情感障碍。这些疾病可能严重到足以干扰患者的日常功能，并使疾病进程恶化。然而，关于精神共病与AD之间的因果关系，或某些个体易患此类疾病的原因，人们知之甚少。因此，本综述的目的是阐明抑郁症、精神分裂症和双相情感障碍与AD之间的因果关系。
