Migliorelli R, Tesón A, Sabe L, Petracca G, Petracchi M, Leiguarda R, Starkstein S E
Department of Behavioral Neurology, Raúl Carrea Institute of Neurological Research, Buenos Aires, Argentina.
J Neuropsychiatry Clin Neurosci. 1995 Summer;7(3):338-44. doi: 10.1176/jnp.7.3.338.
The authors examined the prevalence and correlates of anosognosia in a consecutive series of patients with probable Alzheimer's disease (AD). Patients were examined with the Anosognosia Questionnaire-Dementia (AQ-D), which showed good reliability and validity. On the basis of the AQ-D scores, patients were divided into those with anosognosia (n = 21) and those without anosognosia (n = 52). Patients with anosognosia showed a significantly longer duration of illness, more severe cognitive impairments and deficits in activities of daily living, and higher mania and pathological laughing scores than AD patients without anosognosia. These findings suggest that anosognosia in AD may be part of a specific neuropsychiatric syndrome.
作者在一系列连续的可能患有阿尔茨海默病（AD）的患者中研究了疾病失认症的患病率及其相关因素。使用失认症问卷 - 痴呆版（AQ - D）对患者进行检查，该问卷显示出良好的信度和效度。根据AQ - D评分，将患者分为患有疾病失认症的患者（n = 21）和未患有疾病失认症的患者（n = 52）。与未患有疾病失认症的AD患者相比，患有疾病失认症的患者病程明显更长，认知障碍和日常生活活动缺陷更严重，躁狂和病理性发笑评分更高。这些发现表明，AD中的疾病失认症可能是一种特定神经精神综合征的一部分。
