纤连蛋白衍生肽PHSRN诱导快速上皮化相关的角膜基质恢复：2例持续性上皮缺损所致角膜穿孔病例报告
Recovery of the Corneal Stroma Associated With Rapid Reepithelialization Induced by the Fibronectin-Derived Peptide PHSRN in 2 Cases of Corneal Perforation Due to a Persistent Epithelial Defect.
作者信息
Morita Yukiko, Morishige Naoyuki, Yamada Naoyuki, Ohta Manami, Sonoda Koh-Hei, Nishida Teruo
机构信息
Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Japan.
出版信息
Cornea. 2015 Nov;34(11):1504-7. doi: 10.1097/ICO.0000000000000592.
PURPOSE
To report 2 cases of corneal perforation associated with a persistent epithelial defect (PED), which were treated with eye drops containing the fibronectin-derived peptide PHSRN (Pro-His-Ser-Arg-Asn).
METHODS
A 67-year-old man and a 58-year-old man presented with corneal perforation associated with a PED caused by lagophthalmos. PHSRN eye drops were administered 4 times a day to both patients.
RESULTS
Both patients experienced healing of the epithelial defect and closure of corneal perforation within 3 or 4 days after the onset of PHSRN treatment. Anterior segment optical coherence tomography also revealed recovery of corneal stromal thickness at the lesion site.
CONCLUSIONS
PHSRN eye drops were effective for the treatment of corneal perforation due to the PED, with rapid reepithelialization being followed by full restoration of stromal thickness.
目的
报告2例与持续性上皮缺损（PED）相关的角膜穿孔病例，采用含有纤连蛋白衍生肽PHSRN（脯氨酸-组氨酸-丝氨酸-精氨酸-天冬酰胺）的滴眼液进行治疗。
方法
一名67岁男性和一名58岁男性因睑裂闭合不全导致角膜穿孔并伴有PED。两名患者均每天使用4次PHSRN滴眼液。
结果
两名患者在开始使用PHSRN治疗后3或4天内，上皮缺损愈合，角膜穿孔闭合。眼前节光学相干断层扫描还显示病变部位角膜基质厚度恢复。
结论
PHSRN滴眼液对治疗PED引起的角膜穿孔有效，能使上皮快速再生，随后基质厚度完全恢复。
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