Rudinsky A J, Clark E S, Russell D S, Gilor C
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.
Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.
Aust Vet J. 2015 Sep;93(9):327-31. doi: 10.1111/avj.12354.
A 13-year-old male castrated Domestic Shorthair cat was presented for investigation of lethargy, vomiting, polydipsia and polyuria. Glucocorticoid-deficient hypoadrenocorticism was suspected based on hypocholesterolaemia, hypoglycaemia and lack of a stress leucogram, and confirmed with an ACTH stimulation test. Pituitary disease was suspected based on the clinical signs and the combination of hyposthenuria and hypernatraemia. Necropsy revealed bilaterally symmetric adrenocortical atrophy and the changes in the pituitary gland were suggestive of a T-cell-rich immune-mediated panhypophysitis.
Secondary adrenal insufficiency and panhypophysitis have not been previously reported in the cat. This report should raise awareness of this rare but potentially treatable disease process.
一只13岁已去势的家养短毛雄性猫因嗜睡、呕吐、多饮和多尿前来接受检查。基于低胆固醇血症、低血糖症和缺乏应激白细胞象，怀疑为糖皮质激素缺乏性肾上腺皮质功能减退症，并通过促肾上腺皮质激素刺激试验得以确诊。根据临床症状以及低渗尿和高钠血症的组合，怀疑存在垂体疾病。尸检显示双侧肾上腺皮质萎缩，垂体的变化提示为富含T细胞的免疫介导性全垂体炎。
猫继发性肾上腺功能不全和全垂体炎此前未见报道。本报告应提高对这种罕见但可能可治疗的疾病过程的认识。
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