Kurisu Satoshi, Iwasaki Toshitaka, Abe Nobukazu, Tamura Megumi, Ikenaga Hiroki, Watanabe Noriaki, Higaki Tadanao, Shimonaga Takashi, Ishibashi Ken, Dohi Yoshihiro, Fukuda Yukihiro, Kihara Yasuki
Departments of aCardiovascular Medicine bClinical Radiology, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Nucl Med Commun. 2015 Nov;36(11):1127-33. doi: 10.1097/MNM.0000000000000369.
We assessed the accuracy of left ventricular end-diastolic volume (EDV), end-systolic volume (ESV), and ejection fraction (EF) using quantitative gated single-photon emission computed tomography (QGS) in comparison with echocardiography as the reference standard. We also assessed the effects of total perfusion deficit (TPD) on the accuracy of QGS measurements.
A total of 258 patients underwent single-photon emission computed tomography and transthoracic echocardiography within 4 weeks of each investigation for evaluating coronary artery disease. Patients were divided into four groups according to TPD scores.
There were 138 patients with no/minimal TPD, 64 patients with small TPD, 35 patients with middle TPD, and 21 patients with large TPD. There were good correlations and agreements in EDV (r=0.87, 0.90, 0.71, and 0.94, respectively), ESV (r=0.92, 0.94, 0.79, and 0.94, respectively), and EF (r=0.61, 0.79, 0.61, and 0.83, respectively) between QGS and echocardiography in patients with any TPD. QGS significantly underestimated EDV and ESV in patients with no/minimal or small TPD, and significantly overestimated ESV in patients with large TPD. QGS significantly underestimated EF in patients with middle or large TPD.
Our results suggest that QGS is a useful tool for assessing the left ventricular volume and function in patients with any TPD, but myocardial perfusion abnormalities should be taken into consideration when interpreting QRS measurements.
我们采用定量门控单光子发射计算机断层扫描（QGS）评估左心室舒张末期容积（EDV）、收缩末期容积（ESV）和射血分数（EF）的准确性，并与作为参考标准的超声心动图进行比较。我们还评估了总灌注缺损（TPD）对QGS测量准确性的影响。
共有258例患者在每项检查的4周内接受了单光子发射计算机断层扫描和经胸超声心动图检查以评估冠状动脉疾病。根据TPD评分将患者分为四组。
无/最小TPD的患者有138例，小TPD的患者有64例，中TPD的患者有35例，大TPD的患者有21例。在任何TPD的患者中，QGS与超声心动图在EDV（分别为r = 0.87、0.90、0.71和0.94）、ESV（分别为r = 0.92、0.94、0.79和0.94）和EF（分别为r = 0.61、0.79、0.61和0.83）方面存在良好的相关性和一致性。在无/最小或小TPD的患者中，QGS显著低估了EDV和ESV，而在大TPD的患者中，QGS显著高估了ESV。在中或大TPD的患者中，QGS显著低估了EF。
我们的结果表明，QGS是评估任何TPD患者左心室容积和功能的有用工具，但在解释QRS测量结果时应考虑心肌灌注异常。
