Bougea Anastasia, Anagnostou Evangelos, Spandideas Nikolaos, Triantafyllou Nikolaos, Kararizou Evangelia
University of Athens Medical School, Athens, Greece.
Einstein (Sao Paulo). 2015 Oct-Dec;13(4):627-35. doi: 10.1590/S1679-45082015RW3308. Epub 2015 Aug 21.
Vasculitides comprise a heterogeneous group of autoimmune disorders, occurring as primary or secondary to a broad variety of systemic infectious, malignant or connective tissue diseases. The latter occur more often but their pathogenic mechanisms have not been fully established. Frequent and varied central and peripheral nervous system complications occur in vasculitides and connective tissue diseases. In many cases, the neurological disorders have an atypical clinical course or even an early onset, and the healthcare professionals should be aware of them. The purpose of this brief review was to give an update of the main neurological disorders of common vasculitis and connective tissue diseases, aiming at accurate diagnosis and management, with an emphasis on pathophysiologic mechanisms.
血管炎是一组异质性自身免疫性疾病，可原发性发生，也可继发于多种全身性感染、恶性肿瘤或结缔组织疾病。后者更为常见，但其致病机制尚未完全明确。血管炎和结缔组织疾病常出现各种中枢和周围神经系统并发症。在许多情况下，神经系统疾病具有非典型的临床病程，甚至起病较早，医护人员应予以关注。本简要综述的目的是更新常见血管炎和结缔组织疾病的主要神经系统疾病，旨在实现准确诊断和管理，重点关注病理生理机制。
