Simon Neil G, Kiernan Matthew C
Brain and Mind Research Institute, Sydney Medical School, The University of Sydney, Australia; Prince of Wales Clinical School, University of New South Wales, Australia.
Brain and Mind Research Institute, Sydney Medical School, The University of Sydney, Australia.
Neuromuscul Disord. 2015 Nov;25(11):904-7. doi: 10.1016/j.nmd.2015.07.012. Epub 2015 Jul 23.
Multifocal acquired demyelinating sensory and motor neuropathy is characterised by multifocal clinical deficits. Imaging studies have identified multifocal enlargements of nerve trunks, but a precise correlation between structural abnormalities and electrophysiological dysfunction has not been elucidated. Two patients diagnosed with multifocal acquired demyelinating sensory and motor neuropathy were evaluated with nerve conduction studies, including short segment nerve conduction studies to precisely localise motor conduction block, and ultrasound studies of corresponding nerve trunks. Motor conduction block was identified in each patient (upper limb nerves in two patients), superimposed on additional demyelinating neurophysiological features. Upper limb ultrasound studies demonstrated focal nerve enlargement that precisely correlated with neurophysiological conduction block. The results of this study suggest that factors contributing to focal structural abnormalities in multifocal acquired demyelinating sensory and motor neuropathy are also those that produce conduction block.
多灶性获得性脱髓鞘感觉和运动神经病的特征是多灶性临床缺陷。影像学研究已发现神经干多灶性增粗，但结构异常与电生理功能障碍之间的确切关联尚未阐明。对两名诊断为多灶性获得性脱髓鞘感觉和运动神经病的患者进行了神经传导研究评估，包括用于精确定位运动传导阻滞的短节段神经传导研究，以及对相应神经干的超声研究。两名患者均发现有运动传导阻滞（两名患者的上肢神经），并伴有其他脱髓鞘神经生理特征。上肢超声研究显示局灶性神经增粗，与神经生理传导阻滞精确相关。本研究结果表明，导致多灶性获得性脱髓鞘感觉和运动神经病局灶性结构异常的因素也是产生传导阻滞的因素。
