Anstaett Philipp, Pierroz Vanessa, Ferrari Stefano, Gasser Gilles
Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Photochem Photobiol Sci. 2015 Oct;14(10):1821-5. doi: 10.1039/c5pp00245a.
The activity of two cyclooxygenase-2 enzyme inhibitors, Celecoxib and Lumiracoxib, could be suppressed by coupling to photo-labile protecting groups, so-called photocages. These groups could be further functionalized with a peptide targeting vector for specific cellular delivery. The enzyme inhibition potential of the cyclooxygenase-2 inhibitors could be regained upon two-photon excitation with tissue-transparent near-IR light at 800 nm.
两种环氧化酶-2（COX-2）酶抑制剂塞来昔布和鲁米昔布的活性可通过与光不稳定保护基团（即所谓的光笼）偶联而被抑制。这些基团可用靶向肽载体进一步功能化，以实现特定的细胞递送。在800 nm的组织透明近红外光双光子激发下，环氧化酶-2抑制剂的酶抑制潜力得以恢复。
