Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543 (Singapore).
Department of Chemistry, The Chinese University of Hong Kong, Shatin, Hong Kong (China).
Angew Chem Int Ed Engl. 2015 Oct 5;54(41):12102-6. doi: 10.1002/anie.201504724. Epub 2015 Aug 28.
A highly facile, efficient, and enantioselective bromolactamization of olefinic amides was effected by a carbamate catalyst and ethanol additive. The amide substrates underwent N-cyclization predominantly to give a diverse range of enantioenriched bromolactam products containing up to two stereogenic centers.
通过氨基甲酸酯催化剂和乙醇添加剂，实现了烯烃酰胺的高立体选择性溴内酰胺化反应。酰胺底物主要进行 N-环化反应，得到了多种含有多达两个手性中心的对映体富集的溴内酰胺产物。
