Zhang Juan, Shi Jing-Shu, Li Jian
Jiangxi Provincial Key Laboratory of Hemotologic Diseases, Department of Hematology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
Jiangxi Provincial Key Laboratory of Hemotologic Diseases, Department of Hematology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China. E-mail:
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2015 Aug;23(4):1179-83. doi: 10.7534/j.issn.1009-2137.2015.04.053.
MSC-exosomes are homogeneous menbrane vesicles with diameter 40-100 nm, derived from mesenchymal stem cells at physiological or pathology conditions. MSC-exosomes contain a great quantity and a wide variety of bioactive substances, such as proteins and miRNA. MSC-exosomes transfer bioactive substances to recipient cells to affect their functions through membrane fusion or endocytosis, which like the storage pools of signal vehicles for cell-to-cell comunication in vivo. MSC-exosomes can mimic the beneficial effect of MSC treatment, such as the promotion of tissue repair or the immune regulation. The biological property and functions of MSC-exosomes are reviwed in this article.
间充质干细胞外泌体是直径为40-100nm的均匀膜泡，在生理或病理条件下由间充质干细胞产生。间充质干细胞外泌体含有大量且种类繁多的生物活性物质，如蛋白质和微小RNA。间充质干细胞外泌体通过膜融合或内吞作用将生物活性物质转移至受体细胞以影响其功能，其在体内就如同细胞间通讯信号载体的储存库。间充质干细胞外泌体可模拟间充质干细胞治疗的有益效果，如促进组织修复或免疫调节。本文对间充质干细胞外泌体的生物学特性和功能进行综述。
