Li M Y, Liu D W, Mao Y G
Department of Burns, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Zhonghua Shao Shang Za Zhi. 2017 Mar 20;33(3):180-184. doi: 10.3760/cma.j.issn.1009-2587.2017.03.013.
Exosomes are nano-vesicles released by many kinds of cells. Exosomes play a significant role in cell-to-cell communication and substance transportation through direct effect of signaling molecules on the cell membrane surface, intracellular regulation of cellular content during membrane fusion, or regulation of release of various bioactive molecules. Several studies have reported that culture supernatant of stem cells has some related exosomes to take part in wound repair. The secretion of exosomes is depended on the source and the physiological and pathological condition of deriving cells. How to stimulate the stem cells to produce exosomes maximally and their clinical application are worthy to explore. In this review, we summarize the biological function and application of exosomes derived from stem cells in wound repair.
外泌体是多种细胞释放的纳米囊泡。外泌体通过信号分子对细胞膜表面的直接作用、膜融合过程中细胞内对细胞内容物的调节或各种生物活性分子释放的调节，在细胞间通讯和物质运输中发挥重要作用。多项研究报道，干细胞的培养上清液中有一些相关外泌体参与伤口修复。外泌体的分泌取决于来源细胞的来源以及生理和病理状况。如何最大程度地刺激干细胞产生外泌体及其临床应用值得探索。在本综述中，我们总结了干细胞来源的外泌体在伤口修复中的生物学功能及应用。
