Guo XiaoXuan, Liu Jia, Cai ShengBao, Wang Ou, Ji BaoPing
Beijing Key Laboratory of Functional Food from Plant Resources, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, People's Republic of China.
China National Research Institute of Food and Fermentation Industries, Beijing 100027, People's Republic of China.
Obes Res Clin Pract. 2016 May-Jun;10(3):327-39. doi: 10.1016/j.orcp.2015.08.004. Epub 2015 Aug 25.
The interactions of four natural compounds including apigenin, naringin, emodin and quercetin were investigated on inhibiting 3T3-L1 preadipocyte differentiation and pancreas lipase activity. Oil Red O staining was conducted to visualise and quantify lipid accumulation. The difference between experimental and calculated results was utilised for determining the interaction types. Interestingly, emodin synergistically interacted with the other three compounds, and the combination of emodin and apigenin exhibited the strongest synergistic effect in both differentiation and pancreas lipase assays. Results implied that the combination of apigenin and emodin may be regarded as a promising complementary therapy for management of overweight or obesity.
研究了芹菜素、柚皮苷、大黄素和槲皮素这四种天然化合物在抑制3T3-L1前脂肪细胞分化和胰腺脂肪酶活性方面的相互作用。进行油红O染色以可视化和量化脂质积累。利用实验结果与计算结果之间的差异来确定相互作用类型。有趣的是，大黄素与其他三种化合物具有协同相互作用，并且大黄素和芹菜素的组合在分化和胰腺脂肪酶测定中均表现出最强的协同作用。结果表明，芹菜素和大黄素的组合可能被视为一种有前景的辅助疗法，用于管理超重或肥胖。
