Xu Yajie, Li Xue, Wang Hui
State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China.
Front Nutr. 2022 Apr 15;9:875826. doi: 10.3389/fnut.2022.875826. eCollection 2022.
Apigenin is a flavonoid with antioxidant, anti-inflammatory, and anti-apoptotic activity. In this study, the potential effects of apigenin on cardiometabolic diseases were investigated and . Potential signaling networks in different cell types induced by apigenin were identified, suggesting that the molecular mechanisms of apigenin in cardiometabolic diseases vary with cell types. Additionally, the mechanisms of apigenin-induced biological response in different cardiometabolic diseases were analyzed, including obesity, diabetes, hypertension and cardiovascular diseases. This review provides novel insights into the potential role of apigenin in cardiometabolic diseases.
芹菜素是一种具有抗氧化、抗炎和抗凋亡活性的黄酮类化合物。在本研究中，对芹菜素对心脏代谢疾病的潜在影响进行了调查，并确定了芹菜素在不同细胞类型中诱导的潜在信号网络，这表明芹菜素在心脏代谢疾病中的分子机制因细胞类型而异。此外，还分析了芹菜素在不同心脏代谢疾病中诱导生物反应的机制，包括肥胖、糖尿病、高血压和心血管疾病。本综述为芹菜素在心脏代谢疾病中的潜在作用提供了新的见解。
