Matsuda Katsuya, Yamaryo Takeshi, Akazawa Yuko, Kawakami Kenji, Nakashima Masahiro
Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Hospital, Nagasaki, Japan.
Nagasaki Kawatana Medical Center, Surgery, National Hospital Organization, Nagasaki, Japan.
Pathol Int. 2015 Nov;65(11):603-7. doi: 10.1111/pin.12347. Epub 2015 Aug 27.
We report a case of pleural angiosarcoma in an adult male patient confirmed by autopsy and possibly associated with pneumoconiosis. The lesion was characterized by thickened pleura of both lungs with nodular tumors. Histologically, the tumor was composed of spindle-to-polygonal epithelioid cells that were positive for CD31, CD34, vimentin, and cytokeratin on immunohistochemical staining but were negative for calretinin. Further examination revealed mix-dust pathological findings consistent with the existence of pneumoconiosis; dystrophic ossification, anthracosis, and fractal small dust particles were observed in the lung parenchyma and a hilar lymph node. The current case suggests that pneumoconiosis-associated pathologies may be risk factors for the development of angiosarcoma in the pleura.
我们报告一例经尸检确诊的成年男性胸膜血管肉瘤病例，该病例可能与尘肺有关。病变特征为双肺胸膜增厚并伴有结节状肿瘤。组织学上，肿瘤由梭形至多边形上皮样细胞组成，免疫组化染色显示CD31、CD34、波形蛋白和细胞角蛋白呈阳性，但钙视网膜蛋白呈阴性。进一步检查发现混合性粉尘病理结果与尘肺的存在一致；在肺实质和肺门淋巴结中观察到营养不良性骨化、炭末沉着症和分形小粉尘颗粒。目前的病例表明，尘肺相关病变可能是胸膜血管肉瘤发生的危险因素。
