益生菌在幽门螺杆菌治疗中能发挥作用吗？

Is There a Role for Probiotics in Helicobacter pylori Therapy?

作者信息

Dore Maria P, Goni Elisabetta, Di Mario Francesco

机构信息

Dipartimento di Medicina Clinica e Sperimentale, University of Sassari, Viale San Pietro n 8, Sassari 07100, Italy; Department of Medicine, Michael E. DeBakey VAMC, Baylor College of Medicine, 2002 Holcombe Boulevard, Houston, TX 77030, USA.

Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University, Magdeburg 39106, Germany.

出版信息

Gastroenterol Clin North Am. 2015 Sep;44(3):565-75. doi: 10.1016/j.gtc.2015.05.005. Epub 2015 Jul 22.

DOI:10.1016/j.gtc.2015.05.005

PMID:26314668

Abstract

The role of probiotics in Helicobacter pylori therapy remains unclear. Lactobacilli can be shown to inhibit H pylori in vitro. Some strains of Lactobacilli may exert specific antimicrobial effects. There is no strong evidence of a benefit on eradication rate when probiotics are added to a regimen. Despite promising results obtained using compounds of L reuteri and S boulardii, high-quality trials are needed to define the role of probiotics as adjuvant therapy. Variables that remain to be studied with L reuteri, currently the most promising strain, include dosage, frequency of administration, administration in relation to meals, and duration of therapy.

摘要

益生菌在幽门螺杆菌治疗中的作用仍不明确。体外实验表明，乳酸杆菌可抑制幽门螺杆菌。某些乳酸杆菌菌株可能具有特定的抗菌作用。在治疗方案中添加益生菌时，没有确凿证据表明其对根除率有益。尽管使用罗伊氏乳杆菌和布拉酵母菌的化合物取得了令人鼓舞的结果，但仍需要高质量的试验来确定益生菌作为辅助治疗的作用。目前最有前景的菌株罗伊氏乳杆菌仍有待研究的变量包括剂量、给药频率、与进餐的关系以及治疗持续时间。