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Does day 11 omission of methotrexate due to toxicity influence the outcome in myeloablative hematopoietic cell transplant? Results from a single-center retrospective cohort study.

作者信息

Hamilton B K, Rybicki L, Haddad H, Abounader D, Yurch M, Majhail N S, Hanna R, Sobecks R, Dean R, Liu H, Hill B, Copelan E, Bolwell B, Kalaycio M

机构信息

Bone Marrow Transplant Program, Department of Hematology & Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, USA.

Quantitative Health Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA.

出版信息

Blood Cancer J. 2015 Aug 28;5(8):e344. doi: 10.1038/bcj.2015.70.

DOI:10.1038/bcj.2015.70
PMID:26314986
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4558594/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebc7/4558594/08fcd3e5b386/bcj201570f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebc7/4558594/08fcd3e5b386/bcj201570f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebc7/4558594/08fcd3e5b386/bcj201570f1.jpg

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Does day 11 omission of methotrexate due to toxicity influence the outcome in myeloablative hematopoietic cell transplant? Results from a single-center retrospective cohort study.因毒性反应而在第11天遗漏甲氨蝶呤是否会影响清髓性造血细胞移植的结局？一项单中心回顾性队列研究的结果。
Blood Cancer J. 2015 Aug 28;5(8):e344. doi: 10.1038/bcj.2015.70.
2
Mycophenolate-based graft versus host disease prophylaxis is not inferior to methotrexate in myeloablative-related donor stem cell transplantation.吗替麦考酚酯预防移植物抗宿主病与甲氨蝶呤在清髓性相关供者干细胞移植中疗效相当。
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3
The impact of graft-versus-host disease prophylaxis in reduced-intensity conditioning allogeneic stem cell transplant in acute myeloid leukemia: a study from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation.移植物抗宿主病预防措施对急性髓系白血病减低剂量预处理异基因造血干细胞移植的影响：欧洲血液与骨髓移植组急性白血病工作组的一项研究
Haematologica. 2015 May;100(5):683-9. doi: 10.3324/haematol.2014.119339. Epub 2015 Mar 13.
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A well-tolerated regimen of 800 cGy TBI-fludarabine-busulfan-ATG for reliable engraftment after unmanipulated haploidentical peripheral blood stem cell transplantation in adult patients with acute myeloid leukemia.在成年急性髓系白血病患者中，一种耐受性良好的800厘戈瑞全身照射-氟达拉滨-白消安-抗胸腺细胞球蛋白方案用于非处理单倍体相合外周血干细胞移植后可靠植入。
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Standard versus alternative myeloablative conditioning regimens in allogeneic hematopoietic stem cell transplantation for high-risk acute leukemia.高危急性白血病异基因造血干细胞移植中标准与替代清髓性预处理方案的比较
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EJHaem. 2024 Apr 28;5(3):578-583. doi: 10.1002/jha2.909. eCollection 2024 Jun.
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本文引用的文献

1
Cyclosporine in combination with mycophenolate mofetil versus methotrexate for graft versus host disease prevention in myeloablative HLA-identical sibling donor allogeneic hematopoietic cell transplantation.环孢素联合霉酚酸酯与甲氨蝶呤预防 HLA 相合同胞供者异基因造血细胞移植中移植物抗宿主病。
Am J Hematol. 2015 Feb;90(2):144-8. doi: 10.1002/ajh.23882. Epub 2014 Nov 19.
2
Tailoring the GVHD prophylaxis regimen according to transplantation associated toxicities-Substituting the 3rd dose of methotrexate to mycophenolate mofetil.根据移植相关毒性调整移植物抗宿主病预防方案-用吗替麦考酚酯替代甲氨蝶呤第 3 剂。
Leuk Res. 2014 Aug;38(8):913-7. doi: 10.1016/j.leukres.2014.05.020. Epub 2014 Jun 4.
3
口服霉酚酸酯中断用于预防移植物抗宿主病对单份脐血移植后结局的影响。
Blood Cell Ther. 2024 Apr 19;7(2):41-48. doi: 10.31547/bct-2023-038. eCollection 2024 May 25.
4
Tacrolimus/methotrexate vs tacrolimus/reduced-dose methotrexate/mycophenolate for graft-versus-host disease prevention.他克莫司/甲氨蝶呤与他克莫司/低剂量甲氨蝶呤/霉酚酸酯预防移植物抗宿主病。
Blood Adv. 2023 Aug 22;7(16):4505-4513. doi: 10.1182/bloodadvances.2023010310.
5
Inferior Outcomes with Cyclosporine and Mycophenolate Mofetil after Myeloablative Allogeneic Hematopoietic Cell Transplantation.在清髓性异基因造血细胞移植后，环孢素和霉酚酸酯的预后较差。
Biol Blood Marrow Transplant. 2019 Sep;25(9):1744-1755. doi: 10.1016/j.bbmt.2019.05.019. Epub 2019 May 31.
Omission of day-11 MTX, in combination with tacrolimus, is not associated with increased risk of acute graft-versus-host disease after allo-BMT.
Bone Marrow Transplant. 2013 Feb;48(2):307-9. doi: 10.1038/bmt.2012.128. Epub 2012 Jul 2.
4
Association of drug metabolism gene polymorphisms with toxicities, graft-versus-host disease and survival after HLA-identical sibling hematopoietic stem cell transplantation for patients with leukemia.白血病患者接受人类白细胞抗原（HLA）相合同胞造血干细胞移植后，药物代谢基因多态性与毒性、移植物抗宿主病及生存情况的相关性
Leukemia. 2009 Mar;23(3):545-56. doi: 10.1038/leu.2008.323. Epub 2008 Nov 13.
5
Individual patient data meta-analysis of allogeneic peripheral blood stem cell transplant vs bone marrow transplant in the management of hematological malignancies: indirect assessment of the effect of day 11 methotrexate administration.异基因外周血干细胞移植与骨髓移植治疗血液系统恶性肿瘤的个体患者数据荟萃分析：对第11天给予甲氨蝶呤效果的间接评估
Bone Marrow Transplant. 2006 Oct;38(8):539-46. doi: 10.1038/sj.bmt.1705488. Epub 2006 Sep 4.
6
Donor methylenetetrahydrofolate reductase genotype is associated with graft-versus-host disease in hematopoietic stem cell transplant patients treated with methotrexate.供体亚甲基四氢叶酸还原酶基因型与接受甲氨蝶呤治疗的造血干细胞移植患者的移植物抗宿主病相关。
Bone Marrow Transplant. 2006 Apr;37(8):773-9. doi: 10.1038/sj.bmt.1705319.
7
Mucositis after allogeneic hematopoietic stem cell transplantation: a cohort study of methotrexate- and non-methotrexate-containing graft-versus-host disease prophylaxis regimens.异基因造血干细胞移植后的粘膜炎：一项关于含甲氨蝶呤和不含甲氨蝶呤的移植物抗宿主病预防方案的队列研究。
Biol Blood Marrow Transplant. 2005 May;11(5):383-8. doi: 10.1016/j.bbmt.2005.02.006.
8
Tacrolimus as monotherapy or combined with minidose methotrexate for graft-versus-host disease prophylaxis after allogeneic peripheral blood stem cell transplantation: long-term outcomes.他克莫司单药治疗或联合小剂量甲氨蝶呤用于异基因外周血干细胞移植后移植物抗宿主病的预防：长期疗效
Bone Marrow Transplant. 2004 Sep;34(5):425-31. doi: 10.1038/sj.bmt.1704594.
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A multivariable analysis of factors influencing mucositis after autologous progenitor cell transplantation.
Bone Marrow Transplant. 2002 Nov;30(9):587-91. doi: 10.1038/sj.bmt.1703694.
10
Omission of day +11 methotrexate after allogeneic bone marrow transplantation is associated with increased risk of severe acute graft-versus-host disease.异基因骨髓移植后省略第 +11 天的甲氨蝶呤与严重急性移植物抗宿主病风险增加相关。
Bone Marrow Transplant. 2002 Aug;30(3):161-5. doi: 10.1038/sj.bmt.1703616.