Martínez-Alonso Montserrat, Dusso Adriana, Ariza Gemma, Nabal Maria
Unit of Biostatistics and Methodological Support, IRBLLEIDA, Lleida, Spain
Division of Experimental Nephrology, IRBLLEIDA, Lleida, Spain Bone and Mineral Research Unit, Hospital Universitario Central de Asturias, Oviedo, Spain.
Palliat Med. 2016 Jan;30(1):89-96. doi: 10.1177/0269216315601954. Epub 2015 Aug 27.
A normal vitamin D status is required for bones and muscles to maintain their function and structure, but it also contributes to the functional integrity of other multiple physiologic systems in the body.
To assess the relationship of Vitamin D deficiency with health-related quality-of-life issues, fatigue, and physical functioning in advanced cancer patients.
This is a cross-sectional study.
PATIENTS/SETTINGS: Adults under palliative care, having a locally advanced or metastatic or inoperable solid cancer.
Among 30 patients in palliative care with advanced solid cancer, 90% were vitamin D deficient. Serum Vitamin D concentration was positively correlated with patient-reported absence of fatigue (s = 0.49), and physical and functional well-being (s = 0.44 and s = 0.41, respectively, p < 0.01). Fatigue was the symptom with the highest median impact on their lives and was the only one associated with serum vitamin D (p = 0.031), with lower fatigue in patients with vitamin D concentrations in the third tertile. There was no evidence of a direct association between health-related quality of life and vitamin D status.
The 90% frequency of advanced cancer patients with vitamin D deficiency, together with the positive correlation of vitamin D status with the absence of fatigue and improved physical and functional well-being, points to vitamin D supplementation as a potential therapy to enhance the patient's quality of life.
骨骼和肌肉维持其功能与结构需要正常的维生素D状态，而且它对身体其他多个生理系统的功能完整性也有作用。
评估晚期癌症患者维生素D缺乏与健康相关生活质量问题、疲劳及身体功能之间的关系。
这是一项横断面研究。
患者/研究背景：接受姑息治疗的成年人，患有局部晚期、转移性或无法手术的实体癌。
在30例接受姑息治疗的晚期实体癌患者中，90%维生素D缺乏。血清维生素D浓度与患者报告的无疲劳感（s = 0.49）、身体和功能幸福感（分别为s = 0.44和s = 0.41，p < 0.01）呈正相关。疲劳是对其生活影响最大的症状，且是唯一与血清维生素D相关的症状（p = 0.031），维生素D浓度处于第三个三分位数的患者疲劳程度较低。没有证据表明健康相关生活质量与维生素D状态之间存在直接关联。
晚期癌症患者维生素D缺乏的发生率达90%，以及维生素D状态与无疲劳感、身体和功能幸福感改善之间的正相关，表明补充维生素D作为一种潜在疗法可提高患者生活质量。
