Nkonde-Price Chileshe, Bender Jeffrey R
Penn Heart and Vascular Center for Women's Cardiovascular Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Section of Cardiovascular Medicine, Yale Cardiovascular Research Center, Raymond and Beverly Sackler Cardiovascular Laboratory, Yale University School of Medicine, 300 George Street, Room 773G, New Haven, CT 06511, USA.
Endocrinol Metab Clin North Am. 2015 Sep;44(3):559-64. doi: 10.1016/j.ecl.2015.05.005. Epub 2015 Jun 22.
Cardiovascular disease is the leading cause of death in postmenopausal US women. The contribution of postmenopausal hormone replacement therapy to cardiovascular risk is one of the most controversial women's health topics. Strikingly discordant results, between observational and randomized clinical trials, have been reported. Remaining questions regarding time of hormone therapy initiation are discussed, as are ongoing trials focused on these questions. Cardiovascular concerns, cautions, and current recommendations for use are delineated.
心血管疾病是美国绝经后女性的主要死因。绝经后激素替代疗法对心血管风险的影响是女性健康领域最具争议的话题之一。观察性研究和随机临床试验的结果存在显著差异。文中讨论了激素治疗开始时间仍存在的问题，以及针对这些问题正在进行的试验。还阐述了心血管方面的关注点、注意事项以及当前的使用建议。
