雌激素对身体成分和生物能量学的调节作用。
Regulation of Body Composition and Bioenergetics by Estrogens.
作者信息
Van Pelt Rachael E, Gavin Kathleen M, Kohrt Wendy M
机构信息
Division of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Mailstop B179, Academic Office One, 12631 East 17th Avenue, Room 8111, Aurora, CO 80045, USA.
Division of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Mailstop B179, Academic Office One, 12631 East 17th Avenue, Room 8111, Aurora, CO 80045, USA.
出版信息
Endocrinol Metab Clin North Am. 2015 Sep;44(3):663-76. doi: 10.1016/j.ecl.2015.05.011. Epub 2015 Jun 20.
Abstract
Evidence points to an important role of estradiol (E2) in the regulation of body composition and bioenergetics. Basic and preclinical research shows that the disruption of E2 signaling through either genetic manipulation or surgical intervention accelerates fat accumulation, with a disproportionate increase in abdominal fat. Clinical evidence for the regulation of body composition and bioenergetics by E2 is less consistent. Evidence exists both for and against menopause as the mediator of changes in body composition. Thus, a need remains to better understand the metabolic actions of estrogens in women and the potential impact on health after the menopause.
摘要
有证据表明雌二醇（E2）在身体成分和生物能量学的调节中起着重要作用。基础研究和临床前研究表明，通过基因操作或手术干预破坏E2信号会加速脂肪堆积，腹部脂肪增加尤为明显。关于E2对身体成分和生物能量学调节的临床证据并不一致。关于绝经是否是身体成分变化的介导因素，既有支持的证据，也有反对的证据。因此，仍有必要更好地了解雌激素在女性中的代谢作用以及绝经后对健康的潜在影响。
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