Department of Clinical Biochemistry, Faculty of Medicine, King AbdulAziz University, Jeddah 21465, Saudi Arabia.
Department of Clinical Biochemistry, Faculty of Medicine, University of Jeddah, Jeddah 21959, Saudi Arabia.
Nutrients. 2021 Nov 17;13(11):4127. doi: 10.3390/nu13114127.
This scoping review aims to clarify the interplay between obesity, vitamin D deficiency, cellular senescence, and obesity-related metabolic consequences, mainly subclinical atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). Obesity is a significant global health problem that involves cellular, environmental, behavioral, and genetic elements. The fundamental cause of obesity throughout all life stages is an energy imbalance, and its consequences are countless and, foremost, very common. Obesity has been comprehensively studied in the literature given its association with low serum vitamin D, with many proposed mechanisms linking the two conditions. Moreover, markers of exaggerated cellular senescence have been proven to accumulate in obese individuals. Subclinical atherosclerosis initiates an early stage that ends in serious cardiac events, and obesity, low vitamin D, and senescent cells largely contribute to its associated chronic low-grade inflammation. Furthermore, NAFLD signifies the hepatic manifestation of metabolic syndrome, and studies have highlighted the important role of obesity, vitamin D deficiency, and cellular senescence in its development. Therefore, we outlined the most important mechanisms tying these conditions to one another.
本范围综述旨在阐明肥胖、维生素 D 缺乏、细胞衰老以及与肥胖相关的代谢后果（主要为亚临床动脉粥样硬化和非酒精性脂肪性肝病）之间的相互作用。肥胖是一个重大的全球健康问题，涉及细胞、环境、行为和遗传因素。在所有生命阶段，肥胖的根本原因是能量失衡，其后果不计其数，而且非常常见。鉴于肥胖与血清维生素 D 水平低有关，因此在文献中对肥胖进行了广泛研究，许多研究提出了将这两种情况联系起来的机制。此外，已证实肥胖个体中会积累大量过度的细胞衰老标志物。亚临床动脉粥样硬化始于一个早期阶段，最终会导致严重的心脏事件，而肥胖、低维生素 D 和衰老细胞在其相关的慢性低度炎症中起主要作用。此外，非酒精性脂肪性肝病是代谢综合征在肝脏的表现，研究强调了肥胖、维生素 D 缺乏和细胞衰老在其发病机制中的重要作用。因此，我们概述了将这些情况联系在一起的最重要的机制。
