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宫颈癌近距离治疗中分次间器官变形引起的剂量学变化。

Dosimetric variations due to interfraction organ deformation in cervical cancer brachytherapy.

作者信息

Kobayashi Kazuma, Murakami Naoya, Wakita Akihisa, Nakamura Satoshi, Okamoto Hiroyuki, Umezawa Rei, Takahashi Kana, Inaba Koji, Igaki Hiroshi, Ito Yoshinori, Shigematsu Naoyuki, Itami Jun

机构信息

Department of Radiation Oncology, National Cancer Center Hospital, Chuo-ku, Japan.

Department of Radiation Oncology, National Cancer Center Hospital, Chuo-ku, Japan.

出版信息

Radiother Oncol. 2015 Dec;117(3):555-8. doi: 10.1016/j.radonc.2015.08.017. Epub 2015 Aug 24.

DOI:10.1016/j.radonc.2015.08.017
PMID:26316394
Abstract

We quantitatively estimated dosimetric variations due to interfraction organ deformation in multi-fractionated high-dose-rate brachytherapy (HDRBT) for cervical cancer using a novel surface-based non-rigid deformable registration. As the number of consecutive HDRBT fractions increased, simple addition of dose-volume histogram parameters significantly overestimated the dose, compared with distribution-based dose addition.

摘要

我们使用一种新型的基于表面的非刚性可变形配准方法，对宫颈癌多分割高剂量率近距离放疗（HDRBT）中因分次间器官变形导致的剂量学变化进行了定量估计。随着连续HDRBT分割次数的增加，与基于分布的剂量相加相比，简单相加剂量体积直方图参数会显著高估剂量。

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