肌动蛋白塑造自噬体。
Actin shapes the autophagosome.
机构信息
Department of Molecular Medicine, Insititute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway.
出版信息
Nat Cell Biol. 2015 Sep;17(9):1094-6. doi: 10.1038/ncb3224.
DOI:10.1038/ncb3224
PMID:26316454
Abstract
Compared with most intracellular vesicles, the autophagosome is formed by an unusual event of vesicle budding involving an elusive sequence of membrane expansions that ends with a double membrane vesicle. It is now shown that actin polymerization inside the forming autophagosome is a driving force for the expansion and assembly of a functional autophagosome.
摘要
与大多数细胞内囊泡相比，自噬体的形成是一个不寻常的囊泡出芽事件，涉及一系列难以捉摸的膜扩张序列，最终形成一个双层膜囊泡。现在已经表明，形成中的自噬体内部的肌动蛋白聚合是扩展和组装功能性自噬体的驱动力。
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