全身骨髓腔的增殖和糖酵解评估

Proliferative and Glycolytic Assessment of the Whole-Body Bone Marrow Compartment.

作者信息

Goryawala Mohammed, Adjoua Malek, Güleç Seza

机构信息

Seza Güleç MD, Florida International University Herbert Wertheim College, Department of Surgery, Miami, USA Phone: +17866930821 E-mail:

出版信息

Mol Imaging Radionucl Ther. 2015 Jun 5;24(2):71-9. doi: 10.4274/mirt.22931.

DOI:10.4274/mirt.22931

PMID:26316472

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4563173/

Abstract

OBJECTIVE

Quantitative assessment of active bone marrow (BM) in vivo is yet to be well-defined. This study aims to compare total body BM volume estimations obtained from use of both18F-FLT PET/CT and 18F-FDG PET/CT in order to consolidate higher cellular proliferation rates with imaging the highly active red BM in pancreatic cancer.

METHODS

This phase I pilot study includes seven patients with pancreatic cancers who underwent both 18F-FLT and 18F-FDG imaging each acquired within a week's duration. A CT-based classifier is used for segmenting bone into cortical and trabecular regions. The total BM volume is determined through statistical thresholding on PET activity found within the trabecular bone.

RESULTS

Results showed that 18F-FLT measures of red BM volume (RBV) were higher than those obtained from 18F-FDG (∆=89.21 ml). RBV obtained using 18F-FLT in males were found to have high correlation with measured weight (R2=0.61) and BMI (R2=0.70). The red BM fraction obtained from 18F-FLT was significantly different between males and females, with females showing much higher red bone matter within the trabecular bone (p<0.05). In contrast to 18F-FLT, 18F-FDG BM measurements showed that RBV was significantly different between males and females (p<0.05). Results also show that spinal activity SUV threshold for red BM segmentation is significantly different between 18F-FLT PET and 18F-FDG PET (p<0.05).

CONCLUSION

By combining 18F-FLT-PET and 18F-FDG-PET, this study provides useful insights for in vivo BM estimation through its proliferative and glycolytic activities.

摘要

目的

对体内活跃骨髓（BM）进行定量评估的方法尚未明确界定。本研究旨在比较使用¹⁸F - FLT PET/CT和¹⁸F - FDG PET/CT获得的全身骨髓体积估计值，以便通过对胰腺癌中高活性红骨髓成像来巩固更高的细胞增殖率。

方法

这项I期试点研究纳入了7例胰腺癌患者，他们在一周内分别接受了¹⁸F - FLT和¹⁸F - FDG成像。基于CT的分类器用于将骨骼分割为皮质骨和小梁骨区域。通过对小梁骨内PET活性进行统计阈值化来确定总骨髓体积。

结果

结果显示，¹⁸F - FLT测量的红骨髓体积（RBV）高于¹⁸F - FDG测量值（差值 = 89.21 ml）。发现男性使用¹⁸F - FLT获得的RBV与测量体重（R² = 0.61）和BMI（R² = 0.70）高度相关。¹⁸F - FLT获得的红骨髓分数在男性和女性之间存在显著差异，女性小梁骨内的红骨髓物质含量更高（p < 0.05）。与¹⁸F - FLT不同，¹⁸F - FDG骨髓测量显示男性和女性之间的RBV存在显著差异（p < 0.05）。结果还表明，¹⁸F - FLT PET和¹⁸F - FDG PET之间用于红骨髓分割的脊柱活性SUV阈值存在显著差异（p < 0.05）。