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Thiopurine S-Methyltransferase and Methylenetetrahydrofolate Reductase Polymorphisms in Leukemia.

作者信息

Küpeli Serhan

机构信息

Çukurova University Faculty of Medicine, Department of Pediatric Oncology and Pediatric Bone Marrow Transplantation Unit, Adana, Turkey Phone: +90 322 338 74 44 E-mail:

出版信息

Turk J Haematol. 2015 Jun;32(2):184-5. doi: 10.4274/tjh.2015.0001.

DOI:10.4274/tjh.2015.0001
PMID:26316490
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4451490/
Abstract
摘要

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本文引用的文献

1
Severe Myelotoxicity Associated with Thiopurine S-Methyltransferase*3A/*3C Polymorphisms in a Patient with Pediatric Leukemia and the Effect of Steroid Therapy.一名小儿白血病患者中硫嘌呤 S - 甲基转移酶*3A/*3C 多态性相关的严重骨髓毒性及类固醇治疗的效果
Turk J Haematol. 2014 Dec 5;31(4):276-85. doi: 10.4274/tjh.2013.0082.
2
Thiopurine dose intensity and treatment outcome in childhood lymphoblastic leukaemia: the influence of thiopurine methyltransferase pharmacogenetics.儿童淋巴细胞白血病中硫嘌呤剂量强度与治疗结果：硫嘌呤甲基转移酶药物遗传学的影响
Br J Haematol. 2015 Apr;169(2):228-40. doi: 10.1111/bjh.13240. Epub 2014 Nov 29.
3
Myelotoxicity after high-dose methotrexate in childhood acute leukemia is influenced by 6-mercaptopurine dosing but not by intermediate thiopurine methyltransferase activity.大剂量甲氨蝶呤治疗儿童急性白血病后的骨髓毒性受6-巯基嘌呤剂量影响，但不受硫嘌呤甲基转移酶中间活性影响。
Cancer Chemother Pharmacol. 2015 Jan;75(1):59-66. doi: 10.1007/s00280-014-2613-7. Epub 2014 Oct 28.
4
Testing for thiopurine methyltransferase status for safe and effective thiopurine administration: a systematic review of clinical guidance documents.检测硫嘌呤甲基转移酶状态以安全有效地使用硫嘌呤：临床指南文件的系统评价
Pharmacogenomics J. 2014 Dec;14(6):493-502. doi: 10.1038/tpj.2014.47. Epub 2014 Aug 26.
5
ALL-BFM 95 treatment in Turkish children with acute lymphoblastic leukemia--experience of a single center.土耳其儿童急性淋巴细胞白血病的ALL-BFM 95治疗——单中心经验
Pediatr Hematol Oncol. 2012 Mar;29(2):130-40. doi: 10.3109/08880018.2011.629859.
6
Gene polymorphisms in folate metabolizing enzymes in adult acute lymphoblastic leukemia: effects on methotrexate-related toxicity and survival.叶酸代谢酶基因多态性与成人急性淋巴细胞白血病：甲氨蝶呤相关性毒性和生存的影响。
Haematologica. 2009 Oct;94(10):1391-8. doi: 10.3324/haematol.2009.008326. Epub 2009 Jul 31.
7
Heterozygosity at the TPMT gene locus, augmented by mutated MTHFR gene, predisposes to 6-MP related toxicities in childhood ALL patients.
Leukemia. 2009 May;23(5):971-4. doi: 10.1038/leu.2008.317. Epub 2008 Nov 6.
8
Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia.肌苷三磷酸焦磷酸酶的基因多态性是急性淋巴细胞白血病治疗期间巯嘌呤代谢及毒性的一个决定因素。
Clin Pharmacol Ther. 2009 Feb;85(2):164-72. doi: 10.1038/clpt.2008.154. Epub 2008 Aug 6.
9
Pharmacogenomic effects on therapy for acute lymphoblastic leukemia in children.药物基因组学对儿童急性淋巴细胞白血病治疗的影响。
Pharmacogenomics J. 2003;3(3):128-35. doi: 10.1038/sj.tpj.6500174.