Rivas-Fuentes Selma, Salgado-Aguayo Alfonso, Pertuz Belloso Silvana, Gorocica Rosete Patricia, Alvarado-Vásquez Noé, Aquino-Jarquin Guillermo
1. Department of Biochemistry Research, National Institute of Respiratory Diseases "Ismael Cosío Villegas", Mexico City, Mexico.
2. Laboratory of Research on Rheumatic Diseases, National Institute of Respiratory Diseases "Ismael Cosío Villegas", Mexico City, Mexico.
J Cancer. 2015 Aug 7;6(10):938-52. doi: 10.7150/jca.12286. eCollection 2015.
Non-small cell lung cancer (NSCLC) is one of the most common types of aggressive cancer. The tumor tissue, which shows an active angiogenesis, is composed of neoplastic and stromal cells, and an abundant inflammatory infiltrate. Angiogenesis is important to support tumor growth, while infiltrating cells contribute to the tumor microenvironment through the secretion of growth factors, cytokines and chemokines, important molecules in the progression of the disease. Chemokines are important in development, activation of the immune response, and physiological angiogenesis. Chemokines have emerged as important regulators in the pathophysiology of cancer. These molecules are involved in the angiogenesis/angiostasis balance and in the recruitment of tumor infiltrating hematopoietic cells. In addition, chemokines promote tumor cell survival, as well as the directing and establishment of tumor cells to metastasis sites. The findings summarized here emphasize the central role of chemokines as modulators of tumor angiogenesis and their potential role as therapeutic targets in the inflammatory process of NSCLC angiogenesis.
非小细胞肺癌（NSCLC）是侵袭性癌症中最常见的类型之一。肿瘤组织呈现活跃的血管生成，由肿瘤细胞和基质细胞组成，并伴有大量炎性浸润。血管生成对支持肿瘤生长很重要，而浸润细胞通过分泌生长因子、细胞因子和趋化因子来促进肿瘤微环境的形成，这些都是疾病进展中的重要分子。趋化因子在发育、免疫反应激活和生理性血管生成中起着重要作用。趋化因子已成为癌症病理生理学中的重要调节因子。这些分子参与血管生成/血管生成抑制平衡以及肿瘤浸润造血细胞的募集。此外，趋化因子可促进肿瘤细胞存活，并引导肿瘤细胞到达转移部位并在那里定植。此处总结的研究结果强调了趋化因子作为肿瘤血管生成调节剂的核心作用及其在NSCLC血管生成炎症过程中作为治疗靶点的潜在作用。
