Parihar Jaspreet S, Tunuguntla Hari S G R
Division of Urology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Hospital, New Brunswick, NJ.
Rev Urol. 2014;16(3):118-21.
With new frontiers of pharmaceutical therapies focusing on tumor growth and angiogenesis, understanding the interaction between immune system and tumor microenvironment has become ever more important. Chemokines and chemokine receptors appear to play an integral role in tumor characteristics. Evidence suggests CXCR4, CXCL5, CXCR7, and stromal derived factor-1 appear to be crucial in survival, growth, and metastasis of renal cell carcinoma. As the role of chemokines in renal cancer is becoming more evident, further research will lead to a better understanding of tumor biology and the development of new therapeutic targets to help improve survival.
随着药物治疗的新前沿聚焦于肿瘤生长和血管生成，了解免疫系统与肿瘤微环境之间的相互作用变得愈发重要。趋化因子和趋化因子受体似乎在肿瘤特征中发挥着不可或缺的作用。有证据表明，CXCR4、CXCL5、CXCR7和基质衍生因子-1在肾细胞癌的存活、生长和转移中似乎至关重要。随着趋化因子在肾癌中的作用变得越来越明显，进一步的研究将有助于更好地理解肿瘤生物学，并开发新的治疗靶点以提高生存率。
