Lindberg Jennifer, Rickardsson Emilie, Andersen Margrethe, Lund Lars
Clinical Institute, University of Southern Denmark, Odense, Denmark.
Department of Urology, Odense University Hospital, Odense C, Denmark.
Res Rep Urol. 2015 Aug 14;7:113-6. doi: 10.2147/RRU.S72119. eCollection 2015.
To establish an animal model of a vesicovaginal fistula that can later be used in the development of new treatment modalities.
Six female pigs of Landrace/Yorkshire breed were used. Vesicotomy was performed through open surgery. An standardized incision between the bladder and the vagina was made, and the mucosa between them was sutured together with absorbable sutures. A durometer ureteral stent was introduced into the fistula, secured with sutures to the bladder wall, allowing for the formation of a persistent fistula tract. Six weeks postoperatively cystoscopy was performed to examine the fistula in vivo. Thereafter, the pigs were euthanized with intravenous pentobarbital.
Two out of four (50%) pigs developed persistent fistulas. No per- or postoperative complications occurred.
This study indicates that this pig model of vesicovaginal fistula can be an effective and cheap way to create a fistula between the bladder and vagina.
建立一种膀胱阴道瘘动物模型，以供后续用于开发新的治疗方法。
使用6只长白/约克夏品种的雌性猪。通过开放手术进行膀胱切开术。在膀胱和阴道之间做一个标准化切口，并用可吸收缝线将它们之间的黏膜缝合在一起。将一个硬度计输尿管支架插入瘘管，用缝线固定在膀胱壁上，以形成持续的瘘管通道。术后6周进行膀胱镜检查以在体内检查瘘管。此后，用静脉注射戊巴比妥对猪实施安乐死。
4只猪中有2只（50%）形成了持续性瘘管。未发生围手术期或术后并发症。
本研究表明，这种膀胱阴道瘘猪模型可能是在膀胱和阴道之间创建瘘管的一种有效且廉价的方法。
