Violaris Konstantinos, Katsarides Vasileios, Karakyriou Maria, Sakellariou Pavlos
Neurosurgery Department, Nicosia General Hospital, Nicosia, Cyprus.
Neurosurgery Department, Interbalkan Hospital, Thessaloniki, Greece.
Neurosci J. 2013;2013:706481. doi: 10.1155/2013/706481. Epub 2012 Nov 5.
Aim. To evaluate the frequency of atypical and malignant meningiomas and analyze recurrence rate; to study the morbidity and mortality of these tumors compared to benign meningiomas. Methods. During 1992-2007, 16 patients with malignant and 16 patients with atypical meningioma were operated in Neurosurgery Department of Thessaloniki's Papanikolaou Hospital. We analyzed tumor histology, location, and extent of surgical resection with respect to tumor reappearance and patients' outcome and compared the behavior of benign versus nonbenign meningiomas. Results. Malignant meningiomas accounted for 4.4% (16 patients) and atypical meningiomas for another 4.4% of the series of patients (353) who were operated for intracranial meningioma at our department that period. Malignant meningiomas recurred at a rate of 75% and atypical meningiomas recurred at a rate of 41.6%. There was a significant association of the histological classification (benign, atypical, and malignant) with recurrence (P < 0.01). The recurrence rate after complete resection was 13.8%. The recurrence rate for incomplete resection was 46.7%. Extent of tumor removal was significant to recurrence (P < 0.001) for benign as well for atypical and malignant meningiomas. Tumor location (P > 0.05) was not significant to recurrence. Conclusions. Atypical and malignant meningiomas appeared at a rate of 8.8% of our series of intracranial meningiomas. They showed a significant predisposition to recur. These rare subtypes have higher morbidity and mortality rates than benign meningiomas. Recurrence depends primarily on the extent of surgical removal and on the histological characterization of the tumor as atypical or malignant.
目的。评估非典型和恶性脑膜瘤的发生率并分析复发率；研究这些肿瘤与良性脑膜瘤相比的发病率和死亡率。方法。在1992年至2007年期间，萨洛尼卡的帕帕尼科拉乌医院神经外科对16例恶性脑膜瘤患者和16例非典型脑膜瘤患者进行了手术。我们分析了肿瘤组织学、位置以及手术切除范围与肿瘤复发和患者预后的关系，并比较了良性与非良性脑膜瘤的行为。结果。在我们科室该时期接受颅内脑膜瘤手术的患者系列（353例）中，恶性脑膜瘤占4.4%（16例患者），非典型脑膜瘤占另外4.4%。恶性脑膜瘤的复发率为75%，非典型脑膜瘤的复发率为41.6%。组织学分类（良性、非典型和恶性）与复发之间存在显著关联（P < 0.01）。完全切除后的复发率为13.8%。不完全切除的复发率为46.7%。肿瘤切除范围对良性以及非典型和恶性脑膜瘤的复发均有显著影响（P < 0.001）。肿瘤位置（P > 0.05）对复发无显著影响。结论。非典型和恶性脑膜瘤在我们的颅内脑膜瘤系列中出现的比例为8.8%。它们显示出显著的复发倾向。这些罕见亚型的发病率和死亡率高于良性脑膜瘤。复发主要取决于手术切除范围以及肿瘤的组织学特征是典型还是恶性。
