Fountain Daniel M, Soon Wai Cheong, Matys Tomasz, Guilfoyle Mathew R, Kirollos Ramez, Santarius Thomas
Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Department of Neurosurgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Acta Neurochir (Wien). 2017 Mar;159(3):435-445. doi: 10.1007/s00701-016-3071-2. Epub 2017 Jan 18.
Tumour growth has been used to successfully predict progression-free survival in low-grade glioma. This systematic review sought to establish the evidence base regarding the correlation of volumetric growth rates with histological diagnosis and potential to predict clinical outcome in patients with meningioma.
This systematic review was conducted according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Databases were searched for full text English articles analysing volumetric growth rates in patients with a meningioma.
Four retrospective cohort studies were accepted, demonstrating limited evidence of significantly different tumour doubling rates and shapes of growth curves between benign and atypical meningiomas. Heterogeneity of patient characteristics and timing of volumetric assessment, both pre- and post-operatively, limited pooled analysis of the data. No studies performed statistical analysis to demonstrate the clinical utility of growth rates in predicting clinical outcome.
This systematic review provides limited evidence in support of the use of volumetric growth rates in meningioma to predict histological diagnosis and clinical outcome to guide future monitoring and treatment.
肿瘤生长已被成功用于预测低级别胶质瘤的无进展生存期。本系统评价旨在确立关于体积生长率与组织学诊断的相关性以及预测脑膜瘤患者临床结局的潜力的证据基础。
本系统评价按照PRISMA（系统评价与Meta分析优先报告条目）指南进行。检索数据库以查找分析脑膜瘤患者体积生长率的全文英文文章。
四项回顾性队列研究被纳入，显示出有限的证据表明良性和非典型脑膜瘤之间肿瘤倍增率和生长曲线形状存在显著差异。患者特征以及术前和术后体积评估时间的异质性限制了对数据的汇总分析。没有研究进行统计分析以证明生长率在预测临床结局方面的临床效用。
本系统评价提供了有限的证据支持在脑膜瘤中使用体积生长率来预测组织学诊断和临床结局，以指导未来的监测和治疗。
