中风幸存者中的甘油三酯悖论：一项前瞻性研究。
The Triglyceride Paradox in Stroke Survivors: A Prospective Study.
作者信息
Jain Minal, Jain Anunaya, Yerragondu Neeraja, Brown Robert D, Rabinstein Alejandro, Jahromi Babak S, Vaidyanathan Lekshmi, Blyth Brian, Stead Latha Ganti
机构信息
Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14627, USA.
Department of Emergency Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
出版信息
Neurosci J. 2013;2013:870608. doi: 10.1155/2013/870608. Epub 2013 Feb 25.
Objective. The purpose of our study was to understand the association between serum triglycerides and outcomes in acute ischemic stroke (AIS) patients. Methods. A cohort of all adult patients presenting to the Emergency Department (ED) with an AIS from March 2004 to December 2005 were selected. The lipid profile levels were measured within 24 hours of stroke onset. Demographics, admission stroke severity (NIHSS), functional outcome at discharge (modified Rankin Scale (mRS)), and mortality at 3 months were recorded. Results. The final cohort consisted of 334 subjects. A lower level of triglycerides at presentation was found to be significantly associated with worse National Institutes of Health Stroke Scale (NIHSS) (P = 0.004), worse mRS (P = 0.02), and death at 3 months (P = 0.0035). After adjusting for age and gender and NIHSS, the association between triglyceride and mortality at 3 months was not significant (P = 0.26). Conclusion. Lower triglyceride levels seem to be associated with a worse prognosis in AIS.
目的。我们研究的目的是了解急性缺血性卒中（AIS）患者血清甘油三酯与预后之间的关联。方法。选取2004年3月至2005年12月期间因AIS就诊于急诊科（ED）的所有成年患者组成队列。在卒中发作后24小时内测量血脂水平。记录人口统计学资料、入院时卒中严重程度（美国国立卫生研究院卒中量表（NIHSS））、出院时功能预后（改良Rankin量表（mRS））以及3个月时的死亡率。结果。最终队列由334名受试者组成。发现就诊时较低的甘油三酯水平与更差的美国国立卫生研究院卒中量表（NIHSS）评分（P = 0.004）、更差的mRS评分（P = 0.02）以及3个月时的死亡（P = 0.0035）显著相关。在调整年龄、性别和NIHSS后，甘油三酯与3个月时死亡率之间的关联不显著（P = 0.26）。结论。较低的甘油三酯水平似乎与AIS患者更差的预后相关。
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